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239763 Sigma-AldrichCycloheximide - CAS 66-81-9 - Calbiochem

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Cycloheximide - CAS 66-81-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

Primary Target: hFKBP12

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
66-81-9	C₁₅H₂₃NO₄

价格及供货情况

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Description
Overview	An antifungal antibiotic that inhibits protein synthesis in eukaryotes but not prokaryotes. Competitively inhibits hFKBP12 (K_i = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and other cell types. A 100 mg/ml solution of Cycloheximide (Cat. No. 239765) in DMSO (sterile-filtered) is also available.
Catalogue Number	239763
Brand Family	Calbiochem®

References
References	Christner, C., et al. 1999. J. Med. Chem. 42, 3615. Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175. Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149. Waring, P. 1990. J. Biol. Chem. 265, 14476. Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174. Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.

Product Information
CAS number	66-81-9
Form	Off-white solid
Hill Formula	C₁₅H₂₃NO₄
Chemical formula	C₁₅H₂₃NO₄
Structure formula Image
Quality Level	MQ200

Applications

Biological Information
Primary Target	hFKBP12
Primary Target K<sub>i</sub>	3.4 µM
Purity	≥90% by assay

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	MA4375000

Safety Information
R Phrase	R: 28-40-51/53-61 Very toxic if swallowed. Limited evidence of a carcinogenic effect. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. May cause harm to the unborn child.
S Phrase	S: 45-53-61 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use. Avoid release to the environment. Refer to special instructions/safety data sheet.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
239763-1GMCN	07790788048907
239763-5GMCN	07790788048914

Documentation

Cycloheximide - CAS 66-81-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Cycloheximide - CAS 66-81-9 - Calbiochem 分析证书

标题	批号
239763	输入批号

参考

参考信息概述
Christner, C., et al. 1999. J. Med. Chem. 42, 3615. Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175. Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149. Waring, P. 1990. J. Biol. Chem. 265, 14476. Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174. Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.

小册子

标题
Bulk Product Guide

引用

标题

Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	01-March-2019 JSW
Description	An antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (K_i = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, however it inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
Form	Off-white solid
CAS number	66-81-9
RTECS	MA4375000
Chemical formula	C₁₅H₂₃NO₄
Structure formula
Purity	≥90% by assay
Solubility	Chloroform, Ethanol, Methanol, or H₂O (10 mg/ml)
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Merck USA index	14, 2728
References	Christner, C., et al. 1999. J. Med. Chem. 42, 3615. Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175. Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149. Waring, P. 1990. J. Biol. Chem. 265, 14476. Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174. Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
Citation	Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Antibiotics > Antifungal Agents

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Protein Synthesis Inhibitors

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