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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

234610 Sigma-AldrichCongo Red, High Purity - CAS 573-58-0 - Calbiochem

An amyloidophylic dye that specifically stains stacked β sheet aggregates.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
573-58-0	C₃₂H₂₂N₆O₆S₂ · 2Na

价格及供货情况

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Description
Overview	An amyloidophylic dye that specifically stains stacked β sheet aggregates. Useful for staining and visual detection of amyloid deposits. Does not bind to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
Catalogue Number	234610
Brand Family	Calbiochem®
Synonyms	3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na

References
References	Altschuler, S.E., et al. 2012. Biochemistr in press. Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715. Fezoui, Y., et al. 2000. Amyloid 7, 166. Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095. Kramport, M., et al. 2000. Chem. Biol. 7, 855. Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673. Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484. Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768. Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.

References

Altschuler, S.E., et al. 2012. Biochemistr in press.
Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715.
Fezoui, Y., et al. 2000. Amyloid 7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095.
Kramport, M., et al. 2000. Chem. Biol. 7, 855.
Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.

Product Information
CAS number	573-58-0
ATP Competitive	N
Form	Rust crystalline solid
Hill Formula	C₃₂H₂₂N₆O₆S₂ · 2Na
Chemical formula	C₃₂H₂₂N₆O₆S₂ · 2Na
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	An amyloidophylic dye that specifically stains stacked β sheet aggregates
Purity	≥75% (dye content)

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	QK1400000

Safety Information
S Phrase	S: 25 Avoid contact with eyes.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+15°C to +30°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
234610-500MGCN	04055977199635

Documentation

Congo Red, High Purity - CAS 573-58-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Congo Red, High Purity - CAS 573-58-0 - Calbiochem 分析证书

标题	批号
234610	输入批号

参考

参考信息概述
Altschuler, S.E., et al. 2012. Biochemistr in press. Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715. Fezoui, Y., et al. 2000. Amyloid 7, 166. Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095. Kramport, M., et al. 2000. Chem. Biol. 7, 855. Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673. Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484. Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768. Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.

参考信息概述

小册子

标题
Alzheimer's Disease Brochure & Technical Guide

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	22-September-2012 JSW
Synonyms	3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na
Description	An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
Form	Rust crystalline solid
Recommended reaction conditions	Dissolve 0.5 g Congo Red in 80 ml of absolute ethanol. To this solution add 20 ml of 10% NaCl solution (2 g/20 ml of water). Filter before use. Immerse coverslips containing cells or sections into this solution for 3 min at room temperature. Wash with several exchanges of distilled H₂O until the water runs is clear. Dehydrate with ascending alcohol solutions (50%, 70%, 80%, 95% x 2, 100% x 2). Clear with 100% xylene. Mount coverslip onto slide using Permount or other suitable organic mounting medium and view under a microscope. Amyloid deposits will appear red to pink-red. With a polarizing microscope, amyloid deposits show an apple-green birefringence.
CAS number	573-58-0
RTECS	QK1400000
Chemical formula	C₃₂H₂₂N₆O₆S₂ · 2Na
Structure formula
Purity	≥75% (dye content)
Solubility	Ethanol or H₂O (10 mg/ml)
Storage	Protect from light +15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).
Toxicity	Standard Handling
Merck USA index	14, 2498
References	Altschuler, S.E., et al. 2012. Biochemistr in press. Khurana, R., et al. 2001. J. Biol. Chem. 276, 22715. Fezoui, Y., et al. 2000. Amyloid 7, 166. Fezoui, Y., et al. 2000. Nat. Struct. Biol. 7, 1095. Kramport, M., et al. 2000. Chem. Biol. 7, 855. Kuner, P., et al. 2000. J. Biol. Chem. 275, 1673. Caspi, S., et al. 1998. J. Biol. Chem. 273, 3484. Caughey, B., and Race, A.E. 1992. J. Neurochem. 59, 768. Taylor, D.L., et al. 1974. J. Histochem. Cytochem. 22, 1105.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Dyes, Stains and Probes > Amyloid Probes

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