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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

204896 Sigma-AldrichComplement C8, Human

Complement C8, Human, CAS 80295-58-5, is a native glycoprotein composed of three non-identical subunits of 64, (α), 64 (β), and 22 kDa (γ).

Complement C8, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

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概述

Replacement Information

价格及供货情况

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Description
Overview	Native, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64 kDa (α), 64 kDa (β), and 22 kDa (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8 resulting in formation of the C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
Catalogue Number	204896
Brand Family	Calbiochem®

References
References	Steckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997. Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.

Product Information
CAS number	80295-58-5
Form	Liquid
Formulation	In PBS, pH 7.2.
Quality Level	MQ200

Applications

Biological Information
Purity	≥85% by SDS-PAGE
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity	≥150,000 C₈H₅0 units/mg
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Contaminants	IgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
204896-250UGCN	04055977219845

Documentation

Complement C8, Human MSDS

职位
物料安全数据表 (MSDS)

Complement C8, Human 分析证书

标题	批号
204896	输入批号

参考

参考信息概述
Steckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997. Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-August-2009 RFH
Description	Native, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64,000 (α), 64,000 (β), and 22,000 (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8, resulting in formation of C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
Form	Liquid
Formulation	In PBS, pH 7.2.
Concentration Label	Please refer to vial label for lot-specific concentration
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number	80295-58-5
Purity	≥85% by SDS-PAGE
Contaminants	IgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts
Specific activity	≥150,000 C₈H₅0 units/mg
Storage	Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Standard Handling
References	Steckel, E.W., et al. 1980. J. Biol. Chem. 255, 11997. Petersen, B.H., et al. 1976. J. Clin. Invest. 57, 283.

种类

Life Science Research > Proteins and Enzymes > Other Proteins

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