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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

204876 Sigma-AldrichComplement C1q, Human

Complement C1q, Human, CAS 80295-33-6, is a native C1q complement component composed of 18 polypeptide chains consisting of three nonidentical A, B, C subunits of 29, 26, and 19 kDa, respectively.

Complement C1q, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

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概述

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价格及供货情况

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Description
Overview	Native, human C1q complement component. Glycoprotein composed of 18 polypeptide chains consisting of three nonidentical subunits, A, B, and C, of M.W. 29 kDa, 26 kDa, and 19 kDa, respectively. Present in normal human serum at 70 µg/ml. Found in circulating blood plasma complexed with two C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of C1q to immune complexes containing IgG or IgM or to a variety of other activating substances, including C-reactive protein, retroviruses, and mitochondria. Subsequent to C1q binding, C1r and C1s are converted to proteolytic enzymes that are responsible for continuation of activation via the classical pathway.
Catalogue Number	204876
Brand Family	Calbiochem®

References
References	Loos, M., et al. 1980. J. Immunol. 124, 59. Kolb, W.P., et al. 1979. J. Immunol. 122, 2103.

Product Information
CAS number	80295-33-6
Form	Liquid
Formulation	In 300 mM NaCl, 10 mM HEPES, 40% glycerol, pH 7.2.
Quality Level	MQ200

Applications

Biological Information
Biological activity	≥150,000 C1qH50 units/mg and ≥70% C1q activity in normal human serum on a mg/mg basis
Purity	≥90% by SDS-PAGE
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Contaminants	IgG, IgA, IgM, C3, C4, albumin, fibrinogen, α₂-macroglobulin: ≤trace amounts

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
204876-1MGCN	04055977219685

Documentation

Complement C1q, Human MSDS

职位
物料安全数据表 (MSDS)

Complement C1q, Human 分析证书

标题	批号
204876	输入批号

参考

参考信息概述
Loos, M., et al. 1980. J. Immunol. 124, 59. Kolb, W.P., et al. 1979. J. Immunol. 122, 2103.

引用

标题

Baruah, P., et al. 2006. Journal of Leukocyte Biology in press,.

Yuste, J., et al. 2006. Journal of Immunology 176, 6112.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-May-2008 RFH
Description	Native, human C1q complement component. Glycoprotein composed of 18 polypeptide chains consisting of three nonidentical subunits A, B, and C, of M.W. 29,000, 26,000 and 19,000, respectively. Present in normal human serum at 70 µg/ml. Found in circulating blood plasma complexed with two C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of C1q to immune complexes containing IgG or IgM or to a variety of other activating substances, including C-reactive protein, retroviruses, and mitochondria. Subsequent to C1q binding, C1r and C1s are converted to proteolytic enzymes that are responsible for continuation of activation via the classical pathway.
Form	Liquid
Formulation	In 300 mM NaCl, 10 mM HEPES, 40% glycerol, pH 7.2.
Concentration Label	Please refer to vial label for lot-specific concentration
Source	Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number	80295-33-6
Purity	≥90% by SDS-PAGE
Contaminants	IgG, IgA, IgM, C3, C4, albumin, fibrinogen, α₂-macroglobulin: ≤trace amounts
Biological activity	≥150,000 C1qH50 units/mg and ≥70% C1q activity in normal human serum on a mg/mg basis
Storage	Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Standard Handling
References	Loos, M., et al. 1980. J. Immunol. 124, 59. Kolb, W.P., et al. 1979. J. Immunol. 122, 2103.
Citation	Baruah, P., et al. 2006. Journal of Leukocyte Biology in press,. Yuste, J., et al. 2006. Journal of Immunology 176, 6112.

种类

Life Science Research > Proteins and Enzymes > Other Proteins

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