数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

233183 Sigma-AldrichClodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

Primary Target: Osteoclast-mediated bone resorption

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
88416-50-6	CH₂Cl₂O₆P₂Na₂ • 4H₂O

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
233183-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).
Catalogue Number	233183
Brand Family	Calbiochem®
Synonyms	Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

References
References	Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255. Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708. Smith, R., et al. 1971. Lancet 1, 945. Fleisch, H., et al. 1969. Nature 223, 211.

Product Information
CAS number	88416-50-6
ATP Competitive	N
Form	White solid
Hill Formula	CH₂Cl₂O₆P₂Na₂ • 4H₂O
Chemical formula	CH₂Cl₂O₆P₂Na₂ • 4H₂O
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Osteoclast-mediated bone resorption
Primary Target IC<sub>50</sub>	100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells
Purity	≥97% by titration

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	SZ7640700

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
233183-10MGCN	04055977217773

Documentation

Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem 分析证书

标题	批号
233183	输入批号

参考

参考信息概述
Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255. Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708. Smith, R., et al. 1971. Lancet 1, 945. Fleisch, H., et al. 1969. Nature 223, 211.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	29-April-2008 RFH
Synonyms	Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
Description	A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).
Form	White solid
CAS number	88416-50-6
RTECS	SZ7640700
Chemical formula	CH₂Cl₂O₆P₂Na₂ • 4H₂O
Structure formula
Purity	≥97% by titration
Solubility	H₂O (1 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 2371
References	Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255. Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708. Smith, R., et al. 1971. Lancet 1, 945. Fleisch, H., et al. 1969. Nature 223, 211.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > Bisphosphonates

此产品已添加到您的购物车。