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232120
Sigma-AldrichCisplatin - CAS 15663-27-1 - Calbiochem
Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.
More>>Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Less<<
Cisplatin - CAS 15663-27-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.
Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
Catalogue Number
232120
Brand Family
Calbiochem®
Synonyms
CPDC, DDP, cis-Diaminedichloroplatinum
References
References
Hall, M.D., et al. 2014. Cancer Res. In press. Duan, L., et al. 2001. J. Neurooncol.52, 23. Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241. Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.
Toxic if swallowed. Irritating to eyes, respiratory system and skin. May cause cancer. May cause sensitization by inhalation and skin contact.
S Phrase
S: 22-24-37-45-53
Do not breathe dust. Avoid contact with skin. Wear suitable gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Do not freeze
Ok to freeze
Special Instructions
Unstable in solution; reconstitute just prior to use.
Hall, M.D., et al. 2014. Cancer Res. In press. Duan, L., et al. 2001. J. Neurooncol.52, 23. Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241. Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
08-July-2014 JSW
Synonyms
CPDC, DDP, cis-Diaminedichloroplatinum
Description
A platinum coordination complex with potent antineoplastic activity.
Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
Form
Yellow solid
CAS number
15663-27-1
RTECS
TP2450000
Chemical formula
Pt(NH₃)₂Cl₂
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (10 mg/ml), H₂O with 154 mM NaCl (1 mg/ml), or PBS with 140 mM NaCl (1 mg/ml)
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Unstable in solution; reconstitute just prior to use.
Toxicity
Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 2317
References
Hall, M.D., et al. 2014. Cancer Res. In press. Duan, L., et al. 2001. J. Neurooncol.52, 23. Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241. Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.
