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215921 Sigma-AldrichChlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl

Primary Target: Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
69-09-0	C₁₇H₁₉ClN₂S · HCl

价格及供货情况

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Description
Overview	Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀ < 10 µM), and PLA2.
Catalogue Number	215921
Brand Family	Calbiochem®
Synonyms	2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl

References
References	Lee, M.S., et al. 2007. Cancer Res. 67, 11359. Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378. Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393. Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573. Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280. Yamamoto, H. 1993. Toxicol. Lett. 66, 73. Vadas, P., et al. 1986. Agents Actions 19, 194. Marshak, P.R., et al. 1985. Biochemistry 24, 144.

References

Lee, M.S., et al. 2007. Cancer Res. 67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions 19, 194.
Marshak, P.R., et al. 1985. Biochemistry 24, 144.

Product Information
CAS number	69-09-0
ATP Competitive	N
Form	Off-white crystalline solid
Hill Formula	C₁₇H₁₉ClN₂S · HCl
Chemical formula	C₁₇H₁₉ClN₂S · HCl
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Primary Target IC<sub>50</sub>	17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	N
Contaminants	Heavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	SO1750000

Safety Information
R Phrase	R: 25-26-36/37/38 Toxic if swallowed. Very toxic by inhalation. Irritating to eyes, respiratory system and skin.
S Phrase	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Toxic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+15°C to +30°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
215921-500MGCN	07790788048549

Documentation

Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem 分析证书

标题	批号
215921	输入批号

参考

参考信息概述
Lee, M.S., et al. 2007. Cancer Res. 67, 11359. Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378. Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393. Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573. Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280. Yamamoto, H. 1993. Toxicol. Lett. 66, 73. Vadas, P., et al. 1986. Agents Actions 19, 194. Marshak, P.R., et al. 1985. Biochemistry 24, 144.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	25-April-2018 JSW
Synonyms	2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl
Description	Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀ < 10 µM), and PLA2.
Form	Off-white crystalline solid
CAS number	69-09-0
RTECS	SO1750000
Chemical formula	C₁₇H₁₉ClN₂S · HCl
Structure formula
Purity	≥99% by HPLC
Contaminants	Heavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%
Solubility	H₂O (50 mg/ml) or Methanol (10 mg/ml)
Storage	+15°C to +30°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.
Toxicity	Toxic
Merck USA index	14, 2185
References	Lee, M.S., et al. 2007. Cancer Res. 67, 11359. Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378. Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393. Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573. Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280. Yamamoto, H. 1993. Toxicol. Lett. 66, 73. Vadas, P., et al. 1986. Agents Actions 19, 194. Marshak, P.R., et al. 1985. Biochemistry 24, 144.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Sphingomyelinase Kinase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Nitric Oxide Synthase (NOS) Inhibitors

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