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220486 Sigma-AldrichChk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

Chk2 Inhibitor II, BML-277, CAS 516480-79-8 is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Chk2 (IC₅₀ = 15 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

Primary Target: Chk2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
516480-79-8	C₂₀H₁₄ClN₃O₂

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Description
Overview	A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC₅₀ of 15 nM and a K_i of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4⁺ and CD8⁺ T-cells from γ-irradiation-induced apoptosis with an EC₅₀ of 3 µM and 7.6 µM, respectively. Also available as a 25 mM solution in DMSO (Cat. No. 220491).
Catalogue Number	220486
Brand Family	Calbiochem®
Synonyms	2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

References
References	Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.

Product Information
CAS number	516480-79-8
ATP Competitive	Y
Form	Pale yellow solid
Hill Formula	C₂₀H₁₄ClN₃O₂
Chemical formula	C₂₀H₁₄ClN₃O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Chk2
Primary Target IC<sub>50</sub>	15 nM; Ki = 37 nM inhibiting Chk2; EC50 = 3 µM and 7.6 µM in rescuing both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis
Primary Target K<sub>i</sub>	37 nM inhibiting Chk2
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
220486-1MGCN	04055977201147

Documentation

Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem 分析证书

标题	批号
220486	输入批号

参考

参考信息概述
Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-December-2009 RFH
Synonyms	2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Description	A cell-permeable, potent, reversible and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC₅₀ = 15 nM; K_i = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4⁺ and CD8⁺ T-cells from γ-irradiation-induced apoptosis with an EC₅₀ of 3 µM and 7.6 µM, respectively.
Form	Pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	516480-79-8
Chemical formula	C₂₀H₁₄ClN₃O₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Checkpoint Kinase Inhibitors

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