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219465 Sigma-AldrichCelastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem

A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX

Primary Target: 20S proteasome

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
34157-83-0	C₂₉H₃₈O₄

价格及供货情况

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Description
Overview	A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties. It suppresses LPS-induced pro-inflammatory cytokines release in macrophages and monocytes (IC₅₀ = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for PGE₂, and 210 nM for IL-8 and TNF-α), as well as LPS-induced NF-κB activation (IC₅₀ = 270 nM) and NO production (IC₅₀ = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC₅₀ of 2.5 µM. Has also been shown to inhibit lipid peroxidation induced by ADP and Fe²⁺ in rat liver mitochondria (IC₅₀ = 7 µM). Significantly improves the performance in memory, learning, and psychomotor activity in rats. May be useful to minimize inflammation in Alzheimer′s disease (AD).
Catalogue Number	219465
Brand Family	Calbiochem®
Synonyms	Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX

References
References	Yang, H., et al. 2006. Cancer Res. 66, 4758. Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053. Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89. Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341. He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659. Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.

Product Information
CAS number	34157-83-0
ATP Competitive	N
Form	Red crystals
Hill Formula	C₂₉H₃₈O₄
Chemical formula	C₂₉H₃₈O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	20S proteasome
Primary Target IC<sub>50</sub>	2.5 µM inhibiting chymotrypsin-like activity of 20S proteasome
Purity	≥95% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219465-10MGCN	04055977218459

Documentation

Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem 分析证书

标题	批号
219465	输入批号

参考

参考信息概述
Yang, H., et al. 2006. Cancer Res. 66, 4758. Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053. Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89. Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341. He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659. Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-June-2008 RFH
Synonyms	Tripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
Description	A cell-permeable dienone-phenolic triterpene compound with antioxidant and anti-inflammatory properties. It suppresses LPS-induced release of pro-inflammatory cytokines in macrophages and monocytes (IC₅₀ = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for PEG₂, and 210 nM for IL-8 and TNF-α). Also suppresses LPS-induced NF-κB activation (IC₅₀ = 270 nM) and NO production (IC₅₀ = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC₅₀ of 2.5 µM. Shown to inhibit lipid peroxidation induced by ADP and Fe²⁺ in rat liver mitochondria (IC₅₀ = 7 µM). Improves performance in memory, learning, and psychomotor activity in rats. May be useful in minimizing inflammation in Alzheimer's disease animal models.
Form	Red crystals
Intert gas (Yes/No)	Packaged under inert gas
CAS number	34157-83-0
Chemical formula	C₂₉H₃₈O₄
Structure formula
Purity	≥95% by TLC
Solubility	DMSO (5 mg/ml) or Ethanol
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Yang, H., et al. 2006. Cancer Res. 66, 4758. Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053. Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89. Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341. He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659. Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors

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