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219477 Sigma-AldrichCdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem

The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1,4-Dimethoxyacridine-9(10H)-thione

Primary Target: CDK4/D1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
141992-47-4	C₁₅H₁₃NO₂S

价格及供货情况

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Description
Overview	A thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC₅₀ > 100 µM).
Catalogue Number	219477
Brand Family	Calbiochem®
Synonyms	1,4-Dimethoxyacridine-9(10H)-thione

References
References	Kubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.

Product Information
CAS number	141992-47-4
ATP Competitive	N
Form	Brown solid
Hill Formula	C₁₅H₁₃NO₂S
Chemical formula	C₁₅H₁₃NO₂S
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CDK4/D1
Primary Target IC<sub>50</sub>	200 nM against CDK4/D1
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219477-5MGCN	04055977218541

Documentation

Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem 分析证书

标题	批号
219477	输入批号

参考

参考信息概述
Kubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	29-December-2009 RFH
Synonyms	1,4-Dimethoxyacridine-9(10H)-thione
Description	A potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC₅₀ >100 µM).
Form	Brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	141992-47-4
Chemical formula	C₁₅H₁₃NO₂S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (25 mg/ml) or Ethanol (2.5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Kubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors

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