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			96-Well Plate

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219476 Sigma-AldrichCdk4 Inhibitor - CAS 546102-60-7 - Calbiochem

The Cdk4 Inhibitor, also referenced under CAS 546102-60-7, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

Primary Target: CDK4/D1

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
546102-60-7	C₂₀H₁₀BrN₃O₂

价格及供货情况

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Description
Overview	A cell-permeable, unsymmetrical indolocarbazole compound that displays antiproliferative properties. Acts as a potent, selective, reversible and ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 76 nM). It inhibits the activity of other Cdk’s only at much higher concentrations (IC₅₀ = 520 nM and 2.1 µM for Cdk2/E and Cdk1/B, respectively) and shows little activity towards CaMKII, PKA, or GSK-3β (IC₅₀ ≥ 12.4 µM). Shown to inhibit tumor cells growth (IC₅₀ < 3.0 µM in HCT-116 and NCI-H460 cells) by blocking Rb phosphorylation and inducing G1 cell cycle arrest.
Catalogue Number	219476
Brand Family	Calbiochem®
Synonyms	2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

References
References	Zhu, G., et al. 2003. J. Med. Chem. 46, 2027.

Product Information
CAS number	546102-60-7
ATP Competitive	Y
Form	Yellow solid
Hill Formula	C₂₀H₁₀BrN₃O₂
Chemical formula	C₂₀H₁₀BrN₃O₂
Reversible	Y
Structure formula Image

Applications

Biological Information
Primary Target	CDK4/D1
Primary Target IC<sub>50</sub>	76 nM against Cdk4/D1; < 3.0 7micro;M inhibiting tumor cells growth in HCT-116 and NCI-H460 cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219476-1MGCN	04055977218534

Documentation

Cdk4 Inhibitor - CAS 546102-60-7 - Calbiochem 分析证书

标题	批号
219476	输入批号

参考

参考信息概述
Zhu, G., et al. 2003. J. Med. Chem. 46, 2027.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	29-December-2009 RFH
Synonyms	2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Description	A cell-permeable, unsymmetrical indolocarbazole compound that displays antiproliferative properties. Acts as a potent, selective, reversible and ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 76 nM). It inhibits the activity of other Cdk’s only at much higher concentrations (IC₅₀ = 520 nM and 2.1 µM for Cdk2/E and Cdk1/B, respectively) and shows little activity towards CaMKII, PKA, or GSK-3β (IC₅₀ ≥ 12.4 µM). Shown to inhibit tumor cells growth (IC₅₀ < 3.0 µM in HCT-116 and NCI-H460 cells) by blocking Rb phosphorylation and inducing G1 cell cycle arrest.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	546102-60-7
Chemical formula	C₂₀H₁₀BrN₃O₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (1 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Zhu, G., et al. 2003. J. Med. Chem. 46, 2027.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors

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