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217696
Sigma-AldrichCdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem
The Cdk1 Inhibitor, CGP74514A, also referenced under CAS 190654-01-4, controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylat
More>>The Cdk1 Inhibitor, CGP74514A, also referenced under CAS 190654-01-4, controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable and ATP competitive 2,6,9-substituted purine derivative that acts as a potent, selective inhibitor of Cdk1/cyclin B (IC50 = 25 nM). Reported to affect the activities of other kinases only at much higher concentrations (IC50 = 6.1 µM, 125 µM, and > 10 µM for PKCα, PKA, and EGFR, respectively). Shown to induce mitochondrial damage and apoptosis (≥ 3 µM) in several human leukemia cell lines. At lower concentrations (~1 µM), an initial G2M cell cycle arrest was observed in U937 cells, which eventually lead to apoptosis.
Yu. C., et al. 2003. Cancer Res.63, 1822. Dai, Y., et al. 2002. Cell Cycle1, 143. Imbach, P., et al. 1999. Bioorg. Med. Chem. Lett.9, 91.
Product Information
CAS number
190654-01-4
ATP Competitive
Y
Declaration
Sold under license from Novartis Pharma AG.
Form
Off-white solid
Hill Formula
C₁₉H₂₄ClN₇
Chemical formula
C₁₉H₂₄ClN₇
Reversible
N
Structure formula Image
Biological Information
Primary Target
Cdk1/cyclin B
Primary Target IC<sub>50</sub>
25 nM against Cdk1/cyclin B
Purity
≥ 95% by HPLC
Physicochemical Information
Cell permeable
Y
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Irritant
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C
Packaging Information
Packaged under inert gas
Packaged under inert gas
Global Trade Item Number
产品目录编号
GTIN
217696-5MGCN
04055977202328
Documentation
Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem 分析证书
标题
批号
217696
参考
参考信息概述
Yu. C., et al. 2003. Cancer Res.63, 1822. Dai, Y., et al. 2002. Cell Cycle1, 143. Imbach, P., et al. 1999. Bioorg. Med. Chem. Lett.9, 91.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable, potent, reversible, ATP-competitive and selective inhibitor of Cdk1/cyclin B (IC50 = 25 nM). Affects the activities of other kinases only at higher concentrations (IC50 = 6.1 µM for PKCα, 125 µM for PKA, and >10 µM for EGFR). Also reported to induce mitochondrial damage and apoptosis in several human leukemia cell lines (>3 µM). At lower concentrations (~1 µM) an initial G2M cell cycle arrest and eventual apoptosis has been reported to occur in U937 cells.
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
190654-01-4
Chemical formula
C₁₉H₂₄ClN₇
Structure formula
Purity
≥ 95% by HPLC
Solubility
DMSO (10 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C
Toxicity
Irritant
References
Yu. C., et al. 2003. Cancer Res.63, 1822. Dai, Y., et al. 2002. Cell Cycle1, 143. Imbach, P., et al. 1999. Bioorg. Med. Chem. Lett.9, 91.