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217696 Cdk1 Inhibitor, CGP74514A - CAS 190654-01-4 - Calbiochem

217696
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概述

重要规格表

CAS #Empirical Formula
190654-01-4C₁₉H₂₄ClN₇

价格及供货情况

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217696-5MGCN
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      Description
      OverviewA cell-permeable and ATP competitive 2,6,9-substituted purine derivative that acts as a potent, selective inhibitor of Cdk1/cyclin B (IC50 = 25 nM). Reported to affect the activities of other kinases only at much higher concentrations (IC50 = 6.1 µM, 125 µM, and > 10 µM for PKCα, PKA, and EGFR, respectively). Shown to induce mitochondrial damage and apoptosis (≥ 3 µM) in several human leukemia cell lines. At lower concentrations (~1 µM), an initial G2M cell cycle arrest was observed in U937 cells, which eventually lead to apoptosis.
      Catalogue Number217696
      Brand Family Calbiochem®
      SynonymsCGP74514A, N-(cis-2-Aminocyclohexyl)-N-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine
      References
      ReferencesYu. C., et al. 2003. Cancer Res. 63, 1822.
      Dai, Y., et al. 2002. Cell Cycle 1, 143.
      Imbach, P., et al. 1999. Bioorg. Med. Chem. Lett. 9, 91.
      Product Information
      CAS number190654-01-4
      ATP CompetitiveY
      DeclarationSold under license from Novartis Pharma AG.
      FormOff-white solid
      Hill FormulaC₁₉H₂₄ClN₇
      Chemical formulaC₁₉H₂₄ClN₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetCdk1/cyclin B
      Primary Target IC<sub>50</sub>25 nM against Cdk1/cyclin B
      Purity≥ 95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      产品目录编号 GTIN
      217696-5MGCN 04055977202328