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217713 Sigma-AldrichCdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

The Cdk1/2 Inhibitor II, NU6102, also referenced under CAS 444722-95-6, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine

Primary Target: Cdk1/cyclin B, Cdk2/cyclin A3

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
444722-95-6	C₁₈H₂₂N₆O₃S

价格及供货情况

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Description
Overview	A cell-permeable 2,6-disubstituted purine compound that displays antiproliferative properties. Acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC₅₀ = 9.5 nM and 5.4 nM). Displays greater selectivity for Cdk1/2 over other kinases tested (IC₅₀ = 600 nM, 800 nM, 900 nM and 1.6 µM for ROCKII, PDK1, DYRK1A and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth with a GI₅₀ of 8 µM.
Catalogue Number	217713
Brand Family	Calbiochem®
Synonyms	6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine

References
References	Hardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710. Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079. Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.

Product Information
CAS number	444722-95-6
ATP Competitive	Y
Form	White solid
Hill Formula	C₁₈H₂₂N₆O₃S
Chemical formula	C₁₈H₂₂N₆O₃S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Cdk1/cyclin B, Cdk2/cyclin A3
Primary Target IC<sub>50</sub>	9.5 nM, 5.4 nM against Cdk1/cyclin B, Cdk2/cyclin A3, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
217713-1MGCN	04055977202373

Documentation

Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem 分析证书

标题	批号
217713	输入批号

参考

参考信息概述
Hardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710. Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079. Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-April-2011 RFH
Synonyms	6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
Description	A cell-permeable purine analog that displays anti-proliferative properties and acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC₅₀ = 9.5 nM and 5.4 nM, respectively). Displays greater selectivity for Cdk's over other kinases tested (IC₅₀ = 30 nM, 600 nM, 800 nM, 900 nM, and 1.6 µM for Cdk2/A, ROCKII, PDK1, DYRK1A, and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth (GI₅₀ of 8 µM).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	444722-95-6
Chemical formula	C₁₈H₂₂N₆O₃S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (20 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Hardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710. Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079. Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors

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