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219433 Cathepsin L Inhibitor IV - Calbiochem

概述

Replacement Information

重要规格表

Empirical Formula
C₂₇H₂₉N₃O₄S

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
219433-1MGCN
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      塑胶安瓿;塑胶针药瓶 1 mg
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      Description
      OverviewA potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Also inhibits the release of Ca2+ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
      Catalogue Number219433
      Brand Family Calbiochem®
      Synonyms1-Naphthalenesulfonyl-IW-CHO
      References
      ReferencesYasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
      Product Information
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₇H₂₉N₃O₄S
      Chemical formulaC₂₇H₂₉N₃O₄S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin L
      Primary Target IC<sub>50</sub>1.9 nM against Cathepsin L
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide Sequence1-Naphthalenesulfonyl-Ile-Trp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      219433-1MGCN 04055977218381

      Documentation

      Cathepsin L Inhibitor IV - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Cathepsin L Inhibitor IV - Calbiochem 分析证书

      标题批号
      219433

      参考

      参考信息概述
      Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

      引用

      标题
    • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
    • 数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-January-2019 JSW
      Synonyms1-Naphthalenesulfonyl-IW-CHO
      DescriptionA potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Inhibits the release of Ca2+ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
      FormWhite to off-white solid
      Chemical formulaC₂₇H₂₉N₃O₄S
      Peptide Sequence1-Naphthalenesulfonyl-Ile-Trp-CHO
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
      Citation
    • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.