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219555 Sigma-AldrichCathepsin K Substrate II, Fluorogenic - Calbiochem

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Abz-HPG~GPQ-EDN₂ph

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Replacement Information

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Description
Overview	An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/K_m = 0.426 µM^-1 S^-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK^-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates.
Catalogue Number	219555
Brand Family	Calbiochem®
Synonyms	Abz-HPG~GPQ-EDN₂ph

References
References	Lecaille, F., et al. 2003. Biochem. J. 375, 307.

Product Information
Form	Bright yellow solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₄₀H₅₀N₁₄O₁₂
Chemical formula	C₄₀H₅₀N₁₄O₁₂
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information
Emission max.
Excitation max.
Peptide Sequence	Abz-His-Pro-Gly~Gly-Pro-Gln-EDDnp

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219555-1MGCN	04055977218114

Documentation

Cathepsin K Substrate II, Fluorogenic - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Cathepsin K Substrate II, Fluorogenic - Calbiochem 分析证书

标题	批号
219555	输入批号

参考

参考信息概述
Lecaille, F., et al. 2003. Biochem. J. 375, 307.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	25-August-2009 RFH
Synonyms	Abz-HPG~GPQ-EDN₂ph
Description	An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/K_m = 0.426 µM^-1 S^-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK^-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates. Emission Max: 420 NM, Excitation Max: 320 nM.
Form	Bright yellow solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₄₀H₅₀N₁₄O₁₂
Peptide Sequence	Abz-His-Pro-Gly~Gly-Pro-Gln-EDDnp
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from moisture Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Lecaille, F., et al. 2003. Biochem. J. 375, 307.

种类

Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Protease Substrates

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219555 Sigma-AldrichCathepsin K Substrate II, Fluorogenic - Calbiochem

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

同义词: Abz-HPG~GPQ-EDN₂ph

Recommended Products

概述

价格及供货情况

Documentation

Cathepsin K Substrate II, Fluorogenic - Calbiochem MSDS

Cathepsin K Substrate II, Fluorogenic - Calbiochem 分析证书

参考

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An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

同义词: Abz-HPG~GPQ-EDN₂ph

Recommended Products

价格及供货情况

Cathepsin K Substrate II, Fluorogenic - Calbiochem MSDS

Cathepsin K Substrate II, Fluorogenic - Calbiochem 分析证书

参考

种类

最近查看的内容

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.