Millipore Sigma Vibrant Logo

219379 Cathepsin K Inhibitor II - Calbiochem

The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Cathepsin K Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Inhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc

Primary Target: cathepsin K
View Products on Sigmaaldrich.com
219379
  
正在检索价格......
无法检索价格。
最小订购数量为倍数
Maximum Quantity is
以订单确认为准 更多信息
您节约了 ()。
 
—
Request Pricing
—
目前缺货 目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余：另行通知
      其余：另行通知
      另行通知
      联系客户服务
      Contact Customer Service

       

      联系客户服务

      概述

      Replacement Information

      重要规格表

      Empirical Formula
      C₃₅H₅₁N₇O₈
      Description
      OverviewA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app = 510 nM, 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
      Catalogue Number219379
      Brand Family Calbiochem®
      SynonymsInhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
      References
      ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.
      Product Information
      ATP CompetitiveN
      FormLyophilized white solid
      Hill FormulaC₃₅H₅₁N₇O₈
      Chemical formulaC₃₅H₅₁N₇O₈
      HS Code3504 00 90
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin K
      Primary Target K<sub>i</sub>6 nM against cathepsin; 510 nM, 1.2 µM, against cathepsin B and papain, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceBoc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      219379 0

      Documentation

      Cathepsin K Inhibitor II - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Cathepsin K Inhibitor II - Calbiochem 分析证书

      标题批号
      219379

      参考

      参考信息概述
      Wang, D., et al. 2002. Biochemistry 41, 8849.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-June-2008 RFH
      SynonymsInhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
      DescriptionA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
      FormLyophilized white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₅H₅₁N₇O₈
      Peptide SequenceBoc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.