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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

219461 Sigma-AldrichCathepsin K, His•Tag^®, Human, Recombinant, E. coli

Cathepsin K, His•Tag^®, Human, Recombinant, E. coli, CAS 94716-09-3, of the papain superfamily of cysteine proteinases plays a role in osteoclast-mediated bone resorption and collagen degradation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

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概述

Replacement Information

价格及供货情况

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Description
Overview	Cathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts and recent studies also suggest its expression in fibroblasts. Irregularities in cathepsin K activity, either too high or too low, contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. This recombinant enzyme contains a C-terminal His•Tag^® sequence.
Overview	Note: 1 mU = 1 milliunit.
Catalogue Number	219461
Brand Family	Calbiochem®

References
References	Delaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504. Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231. Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380. Hou, W.S., et al. 2003. Biol. Chem. 384, 891.

Product Information
CAS number	94716-09-3
Unit of Definition	One unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5.
EC number	3.4.22.38
Form	Liquid
Formulation	In 50 mM NaOAC, pH 5.5. The activation was stopped by addition of 10 mM MMTS, which can be removed under reducing conditions.
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by SDS-PAGE
Specific Activity	≥900 mU/mg protein
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219461-25UGCN	04055977218442

Documentation

Cathepsin K, His•Tag^®, Human, Recombinant, E. coli MSDS

职位
物料安全数据表 (MSDS)

Cathepsin K, His•Tag^®, Human, Recombinant, E. coli 分析证书

标题	批号
219461	输入批号

参考

参考信息概述
Delaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504. Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231. Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380. Hou, W.S., et al. 2003. Biol. Chem. 384, 891.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-March-2013 JSW
Description	Cathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts. Recently reported to also be expressed in fibroblasts. Irregularities in activity contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. Contains a C-terminal His•Tag^®.
Form	Liquid
Formulation	In 50 mM NaOAC, pH 5.5. The activation was stopped by addition of 10 mM MMTS, which can be removed under reducing conditions.
Concentration Label	Please refer to vial label for lot-specific concentration
CAS number	94716-09-3
EC number	3.4.22.38
Purity	≥95% by SDS-PAGE
Specific activity	≥900 mU/mg protein
Unit definition	One unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5.
Storage	Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Standard Handling
References	Delaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504. Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231. Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380. Hou, W.S., et al. 2003. Biol. Chem. 384, 891.

种类

Life Science Research > Proteins and Enzymes > Other Enzymes

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219461 Sigma-AldrichCathepsin K, His•Tag^®, Human, Recombinant, E. coli

Cathepsin K, His•Tag^®, Human, Recombinant, E. coli, CAS 94716-09-3, of the papain superfamily of cysteine proteinases plays a role in osteoclast-mediated bone resorption and collagen degradation.

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概述

价格及供货情况

Documentation

Cathepsin K, His•Tag^®, Human, Recombinant, E. coli MSDS

Cathepsin K, His•Tag^®, Human, Recombinant, E. coli 分析证书

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Cathepsin K, His•Tag®, Human, Recombinant, E. coli, CAS 94716-09-3, of the papain superfamily of cysteine proteinases plays a role in osteoclast-mediated bone resorption and collagen degradation.

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Cathepsin K, His•Tag®, Human, Recombinant, E. coli MSDS

Cathepsin K, His•Tag®, Human, Recombinant, E. coli 分析证书

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Cathepsin K, His•Tag^®, Human, Recombinant, E. coli, CAS 94716-09-3, of the papain superfamily of cysteine proteinases plays a role in osteoclast-mediated bone resorption and collagen degradation.

Cathepsin K, His•Tag^®, Human, Recombinant, E. coli MSDS

Cathepsin K, His•Tag^®, Human, Recombinant, E. coli 分析证书