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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

219373 Sigma-AldrichCathepsin G, Human Neutrophil

Cathepsin G, Human Neutrophil, CAS 107200-92-0, is a purified native cathepsin G. Acts as a potent agonist of human platelet activation leading to their aggregation.

Cathepsin G, Human Neutrophil MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

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概述

Replacement Information

价格及供货情况

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Description
Overview	Native cathepsin G from human neutrophil. A serine protease that degrades collagen and proteoglycans. Has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis. Acts as a potent agonist of human platelet activation leading to their aggregation. Reported to be involved in the activation of pro MMP-2 via mechanism requiring MT1-MMP. Inhibited by chymostatin, DFP, and Z-Phe-CH₂Br. Reconstitute in 150 mM NaCl, 50 mM sodium acetate buffer, pH 5.5.
Overview	Note: 1 mU = 1 milliunit.
Catalogue Number	219373
Brand Family	Calbiochem®

References
References	Glusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422. Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197. Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730. Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130. Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144. Maison, C.M., et al. 1991. J. Immunol. 147, 921. Travis, J. 1988. Am. J. Med. 84, 37.

References

Glusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422.
Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197.
Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730.
Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130.
Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144.
Maison, C.M., et al. 1991. J. Immunol. 147, 921.
Travis, J. 1988. Am. J. Med. 84, 37.

Product Information
CAS number	107200-92-0
Unit of Definition	One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-<i>p</i>NA per min at 25°C, pH 7.5.
EC number	3.4.21.20
Form	Salt-free lyophilized solid
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by SDS-PAGE
Source	Prepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity	≥2 units/mg protein

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 6 months at -70°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219373-100MIUCN	04055977201574

Documentation

Cathepsin G, Human Neutrophil MSDS

职位
物料安全数据表 (MSDS)

Cathepsin G, Human Neutrophil 分析证书

标题	批号
219373	输入批号

参考

参考信息概述
Glusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422. Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197. Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730. Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130. Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144. Maison, C.M., et al. 1991. J. Immunol. 147, 921. Travis, J. 1988. Am. J. Med. 84, 37.

参考信息概述

小册子

标题
Cathepsins and Related Products Technical Bulletin

引用

标题

Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.

Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-April-2008 RFH
Description	Native cathepsin G from human neutrophil. A serine protease that degrades collagen and proteoglycans. Has been implicated in connective tissue diseases, such as emphysema and rheumatoid arthritis. Acts as a potent agonist of human platelet activation leading to their aggregation. Inhibited by chymostatins, DFP and Z-Phe-CH₂Br.
Form	Salt-free lyophilized solid
Source	Prepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number	107200-92-0
EC number	3.4.21.20
Purity	≥95% by SDS-PAGE
Specific activity	≥2 units/mg protein
Unit definition	One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-pNA per min at 25°C, pH 7.5.
Solubility	Reconstitute in 50 mM NaOAc and 150 mM NaCl, pH 5.5.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 6 months at -70°C.
Toxicity	Standard Handling
Merck USA index	14, 1905
References	Glusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422. Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197. Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730. Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130. Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144. Maison, C.M., et al. 1991. J. Immunol. 147, 921. Travis, J. 1988. Am. J. Med. 84, 37.
Citation	Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421. Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.

种类

Life Science Research > Proteins and Enzymes > Other Enzymes

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