数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

219401 Sigma-AldrichCathepsin D, Human Liver

Cathepsin D, Human Liver, CAS 9025-26-7, is a purified native cathepsin D from human liver. Overexpression of cathepsin D in is associated with higher risk of cancer relapse and metastasis.

Cathepsin D, Human Liver MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
小册子
Data Sheet

Recommended Products

概述

Replacement Information

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
219401-15UCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	15 u	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
219401-30UCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	30 u	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Native cathepsin D from human liver. A major lysosomal aspartyl protease produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix.
Catalogue Number	219401
Brand Family	Calbiochem®

References
References	Berchem, G., et al. 2002. Oncogene 21, 5951. Barbi, G.P., et al. 1994. Oncology 51, 329. Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586. Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577. Erickson, A. 1989. J. Cell. Biochem. 40, 31.

Product Information
CAS number	9025-26-7
Unit of Definition	One unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
EC number	3.4.23.5
Form	Lyophilized
Formulation	Lyophilized from 2 mM sodium phosphate buffer, pH 6.5.
Quality Level	MQ100

Applications

Biological Information
Purity	≥90% by SDS-PAGE
Source	Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity	≥300 units/mg protein

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219401-15UCN	04055977201710
219401-30UCN	04055977201727

Documentation

Cathepsin D, Human Liver 分析证书

标题	批号
219401	输入批号

参考

参考信息概述
Berchem, G., et al. 2002. Oncogene 21, 5951. Barbi, G.P., et al. 1994. Oncology 51, 329. Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586. Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577. Erickson, A. 1989. J. Cell. Biochem. 40, 31.

小册子

标题
Cathepsins and Related Products Technical Bulletin

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-April-2008 RFH
Description	Native cathepsin D from human liver. Degrades the extracellular matrix and releases growth factors bound to the matrix. Overexpression of cathepsin D in human breast cancers is associated with a higher risk of relapse and metastasis.
Form	Lyophilized
Formulation	Lyophilized from 2 mM sodium phosphate buffer, pH 6.5.
Source	Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number	9025-26-7
EC number	3.4.23.5
Purity	≥90% by SDS-PAGE
Specific activity	≥300 units/mg protein
Unit definition	One unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
Solubility	Sterile H₂O or aqueous buffers. Please see vial label for lot-specific reconstitution volume.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
Toxicity	Standard Handling
Merck USA index	14, 1905
References	Berchem, G., et al. 2002. Oncogene 21, 5951. Barbi, G.P., et al. 1994. Oncology 51, 329. Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586. Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577. Erickson, A. 1989. J. Cell. Biochem. 40, 31.

种类

Life Science Research > Proteins and Enzymes > Other Enzymes

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