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627610 Sigma-AldrichCaspase Inhibitor I - CAS 187389-52-2 - Calbiochem

Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
小册子
Data Sheet
Citations

同义词: Z-VAD (OMe)-FMK

Primary Target: Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
187389-52-2	C₂₂H₃₀FN₃O₇

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
627610-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
627610-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. Shown to enhance the freeze-thaw survival of human embryonic stem cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required.
Catalogue Number	627610
Brand Family	Calbiochem®
Synonyms	Z-VAD (OMe)-FMK

References
References	Heng, B.C., et al. 2007. Biosci. Rep. 27, 257. Martin, U., et al. 2007. Apoptosis 12, 525. Misaghi, S., et al. 2004. Chem. Biol. 11, 1677. Joo, C., et al. 1999. Ophthalmic Res. 31, 287. McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229. Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312. Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735. An, S. and Know, K.A. 1996. FEBS Lett. 386, 115. Cain, K., et al. 1996. Biochem J. 314, 27. Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266. Pronk, G.J., et al. 1996. Science 271, 808. Slee, E.A., et al. 1996. Biochem. J. 315, 21. Chow, S.C., et al. 1995. FEBS Lett. 364, 134. Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283. Zhu, H., et al. 1995. FEBS Lett. 374, 303.

References

Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.
Martin, U., et al. 2007. Apoptosis 12, 525.
Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.
Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
An, S. and Know, K.A. 1996. FEBS Lett. 386, 115.
Cain, K., et al. 1996. Biochem J. 314, 27.
Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266.
Pronk, G.J., et al. 1996. Science 271, 808.
Slee, E.A., et al. 1996. Biochem. J. 315, 21.
Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
Zhu, H., et al. 1995. FEBS Lett. 374, 303.

Product Information
CAS number	187389-52-2
ATP Competitive	N
Form	White solid
Hill Formula	C₂₂H₃₀FN₃O₇
Chemical formula	C₂₂H₃₀FN₃O₇
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
Purity	Single spot by TLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Val-Ala-Asp(OMe)-CH₂F*

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
627610-1MGCN	04055977262810
627610-5MGCN	04055977262841

Documentation

Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem 分析证书

标题	批号
627610	输入批号

参考

参考信息概述
Heng, B.C., et al. 2007. Biosci. Rep. 27, 257. Martin, U., et al. 2007. Apoptosis 12, 525. Misaghi, S., et al. 2004. Chem. Biol. 11, 1677. Joo, C., et al. 1999. Ophthalmic Res. 31, 287. McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229. Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312. Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735. An, S. and Know, K.A. 1996. FEBS Lett. 386, 115. Cain, K., et al. 1996. Biochem J. 314, 27. Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266. Pronk, G.J., et al. 1996. Science 271, 808. Slee, E.A., et al. 1996. Biochem. J. 315, 21. Chow, S.C., et al. 1995. FEBS Lett. 364, 134. Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283. Zhu, H., et al. 1995. FEBS Lett. 374, 303.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Heng, B.C., et al. 2007. Biosci. Rep. 27, 257.

Naohide Watanabe and Eric Lam. 2005. Journal of Biological Chemistry 280, 14691.

Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-February-2012 RFH
Synonyms	Z-VAD (OMe)-FMK
Description	A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.
Form	White solid
CAS number	187389-52-2
Chemical formula	C₂₂H₃₀FN₃O₇
Peptide Sequence	Z-Val-Ala-Asp(OMe)-CH₂F*
Structure formula
Purity	Single spot by TLC
Solubility	DMSO (50 mM)
Storage	Protect from moisture -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Toxicity	Standard Handling
References	Heng, B.C., et al. 2007. Biosci. Rep. 27, 257. Martin, U., et al. 2007. Apoptosis 12, 525. Misaghi, S., et al. 2004. Chem. Biol. 11, 1677. Joo, C., et al. 1999. Ophthalmic Res. 31, 287. McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229. Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312. Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735. An, S. and Know, K.A. 1996. FEBS Lett. 386, 115. Cain, K., et al. 1996. Biochem J. 314, 27. Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266. Pronk, G.J., et al. 1996. Science 271, 808. Slee, E.A., et al. 1996. Biochem. J. 315, 21. Chow, S.C., et al. 1995. FEBS Lett. 364, 134. Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283. Zhu, H., et al. 1995. FEBS Lett. 374, 303.
Citation	Heng, B.C., et al. 2007. Biosci. Rep. 27, 257. Naohide Watanabe and Eric Lam. 2005. Journal of Biological Chemistry 280, 14691. Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors

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