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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

235425 Sigma-AldrichCaspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem

Fluorogenic caspase-3 substrate.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: Ac-DEVD-AMC

Recommended Products

概述

Replacement Information

价格及供货情况

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Description
Overview	Fluorogenic caspase-3 substrate. Cleavage of this substrate by caspase-3 shows Michaelis-Menten kinetics (K_m = 9.7 ± 1.0 µM). Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
Catalogue Number	235425
Brand Family	Calbiochem®
Synonyms	Ac-DEVD-AMC

References
References	Hermission, M., et al. 2000. Oncogene 19, 2338. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W., et al. 1995. Nature 376, 37.

Product Information
CAS number	169332-61-0
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₃₀H₃₇N₅O₁₃
Chemical formula	C₃₀H₃₇N₅O₁₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Fluorogenic caspase-3 substrate
Primary Target IC<sub>50</sub>	Km = 9.7 ± 1.0 µM for cleavage of this substrate by caspase-3
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N
Emission max.
Excitation max.
Peptide Sequence	Ac-Asp-Glu-Val-Asp-AMC

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
235425-1MGCN	04055977217032
235425-5MGCN	04055977217049

Documentation

Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem 分析证书

标题	批号
235425	输入批号

参考

参考信息概述
Hermission, M., et al. 2000. Oncogene 19, 2338. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W., et al. 1995. Nature 376, 37.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-March-2011 RFH
Synonyms	Ac-DEVD-AMC
Description	Fluorogenic CPP32/Apopain substrate. Cleavage of this substrate by CPP32/Apopain shows Michaelis-Menten kinetics (K_m = 9.7 ± 1.0 µM). Cleavage can be monitored by excitation at 380 nm and emission at 460 nm.
Form	Off-white solid
CAS number	169332-61-0
Chemical formula	C₃₀H₃₇N₅O₁₃
Peptide Sequence	Ac-Asp-Glu-Val-Asp-AMC
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mM)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Hermission, M., et al. 2000. Oncogene 19, 2338. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W., et al. 1995. Nature 376, 37.

种类

Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Protease Substrates

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