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264155 Sigma-AldrichCaspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

Caspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: Z-D(OMe)E(Ome)VD(OMe)-FMK

Primary Target: caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
210344-95-9	C₃₀H₄₁FN₄O₁₂

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
264155-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
264155-250UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	250 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
Catalogue Number	264155
Brand Family	Calbiochem®
Synonyms	Z-D(OMe)E(Ome)VD(OMe)-FMK

References
References	Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37.

Product Information
CAS number	210344-95-9
ATP Competitive	N
Form	White to slightly brown solid
Hill Formula	C₃₀H₄₁FN₄O₁₂
Chemical formula	C₃₀H₄₁FN₄O₁₂
Reversible	N
Structure formula Image
Quality Level	MQ200

Applications
Application	Caspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.

Biological Information
Primary Target	caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Purity	≥90% by TLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
264155-1MGCN	04055977198447
264155-250UGCN	04055977198454

Documentation

Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem 分析证书

标题	批号
264155	输入批号

参考

参考信息概述
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-March-2011 RFH
Synonyms	Z-D(OMe)E(Ome)VD(OMe)-FMK
Description	A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
Form	White to slightly brown solid
CAS number	210344-95-9
Chemical formula	C₃₀H₄₁FN₄O₁₂
Peptide Sequence	Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
Structure formula
Purity	≥90% by TLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from moisture -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37.
Citation	Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors

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