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235420 Sigma-AldrichCaspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem

The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: CPP32/Apopain Inhibitor, Ac-DEVD-CHO

Primary Target: Capase-3, capase-6, capase-7, capase-8, capase-10

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
169332-60-9	C₂₀H₃₀N₄O₁₁

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
235420-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A very potent, specific, and reversible inhibitor of caspase-3 (IC₅₀ = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.
Catalogue Number	235420
Brand Family	Calbiochem®
Synonyms	CPP32/Apopain Inhibitor, Ac-DEVD-CHO

References
References	Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37.

Product Information
CAS number	169332-60-9
ATP Competitive	N
Form	White solid
Hill Formula	C₂₀H₃₀N₄O₁₁
Chemical formula	C₂₀H₃₀N₄O₁₁
Reversible	Y
Sold on the basis of peptide content	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Capase-3, capase-6, capase-7, capase-8, capase-10
Primary Target IC<sub>50</sub>	200 pM against caspase-3
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Content	Y
Peptide Sequence	Ac-Asp-Glu-Val-Asp-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
235420-1MGCN	07790788060220
235420-5MGCN	04055977199697

Documentation

Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem 分析证书

标题	批号
235420	输入批号

参考

参考信息概述
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Qian Zhang and Bibhash C. Paria. (2006) Importance of Uterine Cell Death, Renewal and Their Hormonal Regulation in Hamsters That Show Progesterone-dependent Implantation. Endocrinology 147, 2215-2227.

So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375.

Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-March-2011 RFH
Synonyms	CPP32/Apopain Inhibitor, Ac-DEVD-CHO
Description	A specific and reversible inhibitor of CPP32/Apopain/Yama (IC₅₀ = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.
Form	White solid
CAS number	169332-60-9
Chemical formula	C₂₀H₃₀N₄O₁₁
Peptide Sequence	Ac-Asp-Glu-Val-Asp-CHO
Structure formula
Purity	≥90% by HPLC
Solubility	DMSO (5 mg/ml) or H₂O
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37.
Citation	Qian Zhang and Bibhash C. Paria. (2006) Importance of Uterine Cell Death, Renewal and Their Hormonal Regulation in Hamsters That Show Progesterone-dependent Implantation. Endocrinology 147, 2215-2227. So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375. Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors

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