218719 Sigma-AldrichCasein Kinase I Inhibitor III, PF-4800567 - CAS 1188296-52-7 - Calbiochem
The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicati
More>> The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: 3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567
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概述
重要规格表
| CAS # | Empirical Formula |
|---|---|
| 1188296-52-7 | C₁₇H₁₈ClN₅O₂ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 218719-5MGCN |
|
玻璃瓶 | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable pyrazolopyrimidinylamino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKIε with ~22-fold greater potency over CKIδ (IC50 = 32 and 711 nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1 µM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKIε cells over CKIδ-transfected cells (IC50 = 0.13 and 2.65 µM, respectively), and PER2 degradation in COS7-GFP-PER2-CKIε cells. Unlike Casein Kinase I Inhibitor II, PF-670462 (Cat. No. 218716), PF-4800567 exerts only marginal effect on circadian clock under similar conditions. |
| Catalogue Number | 218719 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567 |
| Product Information | |
|---|---|
| CAS number | 1188296-52-7 |
| Form | Beige solid |
| Hill Formula | C₁₇H₁₈ClN₅O₂ |
| Chemical formula | C₁₇H₁₈ClN₅O₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥99% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| 产品目录编号 | GTIN |
| 218719-5MGCN | 04055977218947 |