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218719 Sigma-AldrichCasein Kinase I Inhibitor III, PF-4800567 - CAS 1188296-52-7 - Calbiochem

The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1188296-52-7	C₁₇H₁₈ClN₅O₂

价格及供货情况

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Description
Overview	A cell-permeable pyrazolopyrimidinylamino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKIε with ~22-fold greater potency over CKIδ (IC₅₀ = 32 and 711 nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1 µM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKIε cells over CKIδ-transfected cells (IC₅₀ = 0.13 and 2.65 µM, respectively), and PER2 degradation in COS7-GFP-PER2-CKIε cells. Unlike Casein Kinase I Inhibitor II, PF-670462 (Cat. No. 218716), PF-4800567 exerts only marginal effect on circadian clock under similar conditions.
Catalogue Number	218719
Brand Family	Calbiochem®
Synonyms	3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567

References
References	Meng, Q.J., et al. 2010. Proc. Natl. Acad. Sci. USA 24, 15240. Etchegaray, J.P., et al. 2010. PLoS One 5, e10303. Walton, K.M., et al. 2009. J. Pharmacol. Exp. Ther. 330, 430. Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.

Product Information
CAS number	1188296-52-7
Form	Beige solid
Hill Formula	C₁₇H₁₈ClN₅O₂
Chemical formula	C₁₇H₁₈ClN₅O₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
218719-5MGCN	04055977218947

Documentation

Casein Kinase I Inhibitor III, PF-4800567 - CAS 1188296-52-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Casein Kinase I Inhibitor III, PF-4800567 - CAS 1188296-52-7 - Calbiochem 分析证书

标题	批号
218719	输入批号

参考

参考信息概述
Meng, Q.J., et al. 2010. Proc. Natl. Acad. Sci. USA 24, 15240. Etchegaray, J.P., et al. 2010. PLoS One 5, e10303. Walton, K.M., et al. 2009. J. Pharmacol. Exp. Ther. 330, 430. Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	20-July-2012 JSW
Synonyms	3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567
Description	A cell-permeable pyrazolopyrimidinylamino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKIε with ~22-fold greater potency over CKIδ (IC₅₀ = 32 and 711 nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1 µM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKIε cells over CKIδ-transfected cells (IC₅₀ = 0.13 and 2.65 µM, respectively), and PER2 degradation in COS7-GFP-PER2-CKIε cells. Unlike Casein Kinase I Inhibitor II, PF-670462 (Cat. No. 218716), PF-4800567 exerts only marginal effect on circadian clock under similar conditions.
Form	Beige solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1188296-52-7
Chemical formula	C₁₇H₁₈ClN₅O₂
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Meng, Q.J., et al. 2010. Proc. Natl. Acad. Sci. USA 24, 15240. Etchegaray, J.P., et al. 2010. PLoS One 5, e10303. Walton, K.M., et al. 2009. J. Pharmacol. Exp. Ther. 330, 430. Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Casein Kinase (CK) Inhibitors

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