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A cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca2+ transport and ATP hydrolysis by the sarcolemmal Ca2+/Mg2+-ATPase. Its action is strongly potentiated by phospholipase A2. Inhibits protein kinase C (IC50 = 1.8 µM).
Catalogue Number
217503
Brand Family
Calbiochem®
References
References
Jang, J.Y., et al. 1997. Biochemistry 36, 4635. Huang, J.L., and Trumble, W.R. 1991. Toxicon29, 31. Raynor, R.L., et al. 1991. J. Biol. Chem.266, 2753. Grognet, J.M., et al. 1986. Mol. Immunol.23, 132.
Product Information
CAS number
11061-96-4
Declaration
Not available for sale outside of the United States.
Jang, J.Y., et al. 1997. Biochemistry 36, 4635. Huang, J.L., and Trumble, W.R. 1991. Toxicon29, 31. Raynor, R.L., et al. 1991. J. Biol. Chem.266, 2753. Grognet, J.M., et al. 1986. Mol. Immunol.23, 132.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
13-June-2016 JSW
Description
A cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca2+ transport and ATP hydrolysis by sarcolemmal Ca2+/Mg2+-ATPase. Its action is strongly potentiated by phospholipase A2. Inhibits protein kinase C (IC50 = 1.8 µM).
Form
Lyophilized solid
CAS number
11061-96-4
RTECS
FH7482450
Purity
≥95% by HPLC
Solubility
H₂O (1 mg/ml)
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Harmful
Merck USA index
14, 1835
References
Jang, J.Y., et al. 1997. Biochemistry 36, 4635. Huang, J.L., and Trumble, W.R. 1991. Toxicon29, 31. Raynor, R.L., et al. 1991. J. Biol. Chem.266, 2753. Grognet, J.M., et al. 1986. Mol. Immunol.23, 132.
