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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

215901 Sigma-AldrichCarbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem

The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: CAIX Inhibitor II

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₁₃H₁₂FN₃O₃S

价格及供货情况

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Description
Overview	A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4^Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.
Catalogue Number	215901
Brand Family	Calbiochem®
Synonyms	CAIX Inhibitor II

References
References	Lock, F.E., et al. 2012. Oncogene in press. Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.

Product Information
Form	White solid
Hill Formula	C₁₃H₁₂FN₃O₃S
Chemical formula	C₁₃H₁₂FN₃O₃S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Regulatory Review
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
215901-5MGCN	04055977219227

Documentation

Carbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Carbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem 分析证书

标题	批号
215901	输入批号

参考

参考信息概述
Lock, F.E., et al. 2012. Oncogene in press. Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-December-2012 JSW
Synonyms	CAIX Inhibitor II
Description	A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4^Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₃H₁₂FN₃O₃S
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Regulatory Review
References	Lock, F.E., et al. 2012. Oncogene in press. Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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