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An active constituent of cayenne pepper with excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced responses in rat PC12 cells. Exhibits anti-nociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
Singh, S., et al. 1996. J. Immunol.157, 4412. Nakazawa, K., et al. 1994. Br. J. Pharmacol.113, 296. Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci.12, 517. Takaki, M., et al. 1994. J. Mol. Cell. Cardiol.26, 1227. Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci.11, 330. Pernow, B., et al. 1985. J. Immunol.135, 8125.
Toxic if swallowed. Risk of serious damage to eyes. Danger of serious damage to health by prolonged exposure.
S Phrase
S: 26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Singh, S., et al. 1996. J. Immunol.157, 4412. Nakazawa, K., et al. 1994. Br. J. Pharmacol.113, 296. Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci.12, 517. Takaki, M., et al. 1994. J. Mol. Cell. Cardiol.26, 1227. Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci.11, 330. Pernow, B., et al. 1985. J. Immunol.135, 8125.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
An active constituent of cayenne pepper. Has excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced respones in rat pheochromocytoma cells. Exhibits antinociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
Form
White to pale yellow solid
CAS number
404-86-4
RTECS
RA8530000
Chemical formula
C₁₈H₂₇NO₃
Structure formula
Purity
≥98% by TLC
Solubility
Ethanol
Storage
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity
Toxic
Merck USA index
14, 1768
References
Singh, S., et al. 1996. J. Immunol.157, 4412. Nakazawa, K., et al. 1994. Br. J. Pharmacol.113, 296. Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci.12, 517. Takaki, M., et al. 1994. J. Mol. Cell. Cardiol.26, 1227. Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci.11, 330. Pernow, B., et al. 1985. J. Immunol.135, 8125.
