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208925 Sigma-AldrichCamptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem

A cell-permeable DNA topoisomerase I inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione

Primary Target: DNA topoisomerase 1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
7689-03-4	C₂₀H₁₆N₂O₄

价格及供货情况

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Description
Overview	A cell-permeable DNA topoisomerase I inhibitor. Exhibits anti-leukemic and antitumor properties. Induces apoptosis in HL-60 cells and mouse thymocytes. Arrests cells at the G₂/M phase.
Catalogue Number	208925
Brand Family	Calbiochem®
Synonyms	4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione

References
References	Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475. Staron, K., et al. 1994. Carcinogenesis 15, 2953. Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836. Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249. Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147. Pantazis, P., et al. 1993. Int. J. Cancer 53, 863. Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984. Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629. Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287. Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.

References

Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
Staron, K., et al. 1994. Carcinogenesis 15, 2953.
Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.

Product Information
CAS number	7689-03-4
ATP Competitive	N
Form	Pale yellow solid
Hill Formula	C₂₀H₁₆N₂O₄
Chemical formula	C₂₀H₁₆N₂O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	DNA topoisomerase 1
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	UQ0492000

Safety Information
R Phrase	R: 25-36/37/38-46 Toxic if swallowed. Irritating to eyes, respiratory system and skin. May cause heritable genetic damage.
S Phrase	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
208925-50MGCN	04055977219128

Documentation

Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem 分析证书

标题	批号
208925	输入批号

参考

参考信息概述
Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475. Staron, K., et al. 1994. Carcinogenesis 15, 2953. Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836. Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249. Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147. Pantazis, P., et al. 1993. Int. J. Cancer 53, 863. Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984. Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629. Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287. Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
Tools and Tips for Analyzing Apoptosis

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-July-2009 RFH
Synonyms	4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
Description	A cell-permeable, reversible DNA topoisomerase I inhibitor that binds to and stabilizes the topoisomerase-DNA covalent complex. Possesses antileukemic and antitumor properties. Inhibits Tat-mediated transactivation of HIV-1. Cytostatic for non-tumorigenic cells but cytotoxic for tumorigenic cells. Induces apoptosis of HL-60 cells and mouse thymocytes.
Form	Pale yellow solid
CAS number	7689-03-4
RTECS	UQ0492000
Chemical formula	C₂₀H₁₆N₂O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml) and MeOH (40 mg/ml). Stock solutions made with methanol will remain cloudy.
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity	Toxic & Carcinogenic / Teratogenic
Merck USA index	14, 1735
References	Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475. Staron, K., et al. 1994. Carcinogenesis 15, 2953. Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836. Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249. Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147. Pantazis, P., et al. 1993. Int. J. Cancer 53, 863. Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984. Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629. Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287. Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Topoisomerase Related Inhibitors

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