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208851 Sigma-AldrichCalyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

Calyculin A, CAS 101932-71-2, is a cell-permeable inhibitor of protein phosphatase 2A (IC₅₀ = 0.5-1 nM) and protein phosphatase 1 (PP1; IC₅₀ = 2 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

Primary Target: PP2A

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
101932-71-2	C₅₀H₈₁N₄O₁₅P

价格及供货情况

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Description
Overview	A cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC₅₀ = 0.5-1 nM) and protein phosphatase 1 (PP1; IC₅₀ = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Also known to prevent γ-radiation induced apoptosis in Burkitt’s lymphoma cell line BM13674. Also available as a 100 µM solution in DMSO (Cat. No. 508226).
Catalogue Number	208851
Brand Family	Calbiochem®

References
References	Murakami, N., et al. 1994. Neurosci. Lett. 176, 181. Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803. Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083. Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Carl, A., et al. 1991. Am. J. Physiol. 261, C387. Suganuma, M., et al. 1990. Cancer Res. 50, 3521. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871. Kato, Y., et al. 1988. J. Org. Chem. 53, 3930. Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

References

Murakami, N., et al. 1994. Neurosci. Lett. 176, 181.
Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

Product Information
CAS number	101932-71-2
ATP Competitive	N
Form	Clear film to white crystalline powder
Hill Formula	C₅₀H₈₁N₄O₁₅P
Chemical formula	C₅₀H₈₁N₄O₁₅P
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PP2A
Primary Target IC<sub>50</sub>	0.5-1 nM and 2 nM against protein phosphatase 2A (PP2A) and protein phosphatase 1 (PP1)
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 23/24/25-38 Toxic by inhalation, in contact with skin and if swallowed. Irritating to skin.
S Phrase	S: 26-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Toxic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
208851-10UGCN	04055977219470

Documentation

Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem 分析证书

标题	批号
208851	输入批号

参考

参考信息概述
Murakami, N., et al. 1994. Neurosci. Lett. 176, 181. Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803. Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083. Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Carl, A., et al. 1991. Am. J. Physiol. 261, C387. Suganuma, M., et al. 1990. Cancer Res. 50, 3521. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871. Kato, Y., et al. 1988. J. Org. Chem. 53, 3930. Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
Protein Phosphatases Technical Bulletin

引用

标题

Carole M. Liedtke, Xiangyun Wang and Nicole D. Smallwood. (2005) Role for protein phosphatase 2A in the regulation of calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. Journal of Biological Chemistry 280, 25491-25498.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	29-June-2011 JSW
Description	Cell-permeable protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC₅₀ = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca²⁺-activated K⁺ channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent γ-radiation induced apoptosis in Burkitt's lymphoma cell line BM13674.
Form	Clear film to white crystalline powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	101932-71-2
Chemical formula	C₅₀H₈₁N₄O₁₅P
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO or Ethanol (2 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.
Toxicity	Toxic
References	Murakami, N., et al. 1994. Neurosci. Lett. 176, 181. Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803. Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083. Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Carl, A., et al. 1991. Am. J. Physiol. 261, C387. Suganuma, M., et al. 1990. Cancer Res. 50, 3521. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871. Kato, Y., et al. 1988. J. Org. Chem. 53, 3930. Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
Citation	Carole M. Liedtke, Xiangyun Wang and Nicole D. Smallwood. (2005) Role for protein phosphatase 2A in the regulation of calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. Journal of Biological Chemistry 280, 25491-25498.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors

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