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03-34-0051 Sigma-AldrichCalpeptin - CAS 117591-20-5 - Calbiochem

Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Calpeptin - CAS 117591-20-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: Benzyloxycarbonylleucyl-norleucinal

Primary Target: Calpain-1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
117591-20-5	C₂₀H₃₀N₂O₄

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
03-34-0051-100MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	100 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
03-34-0051-25MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	25 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A cell-permeable calpain inhibitor (ID₅₀ = 52 nM for calpain-1; ID₅₀ = 34 nM for calpain-2; ID₅₀ = 138 nM for papain). Inhibits the Ca²⁺-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca²⁺-ionophore-induced degradation of actin binding protein and P₂₃₅ in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
Catalogue Number	03-34-0051
Brand Family	Calbiochem®
Synonyms	Benzyloxycarbonylleucyl-norleucinal

References
References	Lee, M.S., et al. 2000. Nature 405, 360. Yamazaki, T., et al. 1997. Biochemistry 27, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Shiba, E., et al. 1996. Anticancer Res. 16, 773. Pinter, M., et al. 1994. Neurosci. Lett. 170, 91. Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231. Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

References

Lee, M.S., et al. 2000. Nature 405, 360.
Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Shiba, E., et al. 1996. Anticancer Res. 16, 773.
Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

Product Information
CAS number	117591-20-5
ATP Competitive	N
Form	White to off-white solid
Hill Formula	C₂₀H₃₀N₂O₄
Chemical formula	C₂₀H₃₀N₂O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Biological Information
Primary Target	Calpain-1
Primary Target IC<sub>50</sub>	ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
Purity	≥94% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Leu-Nle-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
03-34-0051-100MGCN	04055977206838
03-34-0051-25MGCN	04055977206845
03-34-0051-5MGCN	04055977206852

Documentation

Calpeptin - CAS 117591-20-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Calpeptin - CAS 117591-20-5 - Calbiochem 分析证书

标题	批号
03-34-0051	输入批号

参考

参考信息概述
Lee, M.S., et al. 2000. Nature 405, 360. Yamazaki, T., et al. 1997. Biochemistry 27, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Shiba, E., et al. 1996. Anticancer Res. 16, 773. Pinter, M., et al. 1994. Neurosci. Lett. 170, 91. Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231. Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

参考信息概述

引用

标题

Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.

Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-October-2007 JSW
Synonyms	Benzyloxycarbonylleucyl-norleucinal
Description	A cell-permeable calpain inhibitor. Inactivates calpain I (ID₅₀ = 52 nM), calpain II (ID₅₀ = 34 nM), and papain (ID₅₀ = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca²⁺-ionophore induced degradation of actin binding protein and P₂₃₅ in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
Form	White to off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	117591-20-5
Chemical formula	C₂₀H₃₀N₂O₄
Peptide Sequence	Z-Leu-Nle-CHO
Structure formula
Purity	≥94% by HPLC
Solubility	DMF (5 mg/ml) or DMSO (5 mg/ml). Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity	Standard Handling
References	Lee, M.S., et al. 2000. Nature 405, 360. Yamazaki, T., et al. 1997. Biochemistry 27, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Shiba, E., et al. 1996. Anticancer Res. 16, 773. Pinter, M., et al. 1994. Neurosci. Lett. 170, 91. Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231. Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
Citation	Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879. Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors

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