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208902 Calpastatin Peptide - Calbiochem

概述

Replacement Information

重要规格表

Empirical Formula
C₁₄₂H₂₃₀N₃₆O₄₄S

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
208902-500UGCN
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      玻璃瓶 500 μg
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      Description
      OverviewA 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).
      Catalogue Number208902
      Brand Family Calbiochem®
      SynonymsCS Peptide
      References
      ReferencesEto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Chemical formulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcalpain 2
      Primary Target IC<sub>50</sub>20 nM against calpain II
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      208902-500UGCN 04055977219500

      Documentation

      Calpastatin Peptide - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Calpastatin Peptide - Calbiochem 分析证书

      标题批号
      208902

      参考

      参考信息概述
      Eto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.

      引用

      标题
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    • 数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCS Peptide
      DescriptionA 27-amino acid, peptide encoded by exon 1B of human calpastatin that acts as a cell-permeable and potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₁₄₂H₂₃₀N₃₆O₄₄S
      Peptide SequenceAc-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml) or 1% Acetic Acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesEto, A., et al. 1995. J. Biol. Chem. 270, 25115.
      Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
      Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.
      Citation
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
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      种类

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors