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208743 Sigma-AldrichCalpain Inhibitor XI - CAS 145731-49-3 - Calbiochem

The Calpain Inhibitor XI, also referenced under CAS 145731-49-3, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Z-L-Abu-CONH(CH₂)₃-morpholine

Primary Target: calpain 1, calpain 2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
145731-49-3	C₂₆H₄₀N₄O₆

价格及供货情况

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Description
Overview	A cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (K_i = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (K_i = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
Catalogue Number	208743
Brand Family	Calbiochem®
Synonyms	Z-L-Abu-CONH(CH₂)₃-morpholine

References
References	Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191. DeBiasi, R.L., et al. 2001. J. Virol. 75, 351. Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66. Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426. Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046. James, T., et al. 1998. J. Neurosci. Res. 51, 218. Li, Z., et al. 1996. J. Med. Chem. 39, 4089. Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428. Bartus, R.T., et al. 1995. Neurol. Res. 17, 249. Bartus, R.T., et al. 1994. Stroke 25, 2265.

References

Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
James, T., et al. 1998. J. Neurosci. Res. 51, 218.
Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Bartus, R.T., et al. 1994. Stroke 25, 2265.

Product Information
CAS number	145731-49-3
ATP Competitive	N
Form	White to off-white solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₂₆H₄₀N₄O₆
Chemical formula	C₂₆H₄₀N₄O₆
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	calpain 1, calpain 2
Primary Target K<sub>i</sub>	140 nM and 41 nM, against calpain-1 and -2, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
208743-5MGCN	04055977202809

Documentation

Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem 分析证书

标题	批号
208743	输入批号

参考

参考信息概述
Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191. DeBiasi, R.L., et al. 2001. J. Virol. 75, 351. Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66. Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426. Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046. James, T., et al. 1998. J. Neurosci. Res. 51, 218. Li, Z., et al. 1996. J. Med. Chem. 39, 4089. Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428. Bartus, R.T., et al. 1995. Neurol. Res. 17, 249. Bartus, R.T., et al. 1994. Stroke 25, 2265.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-May-2011 JSW
Synonyms	Z-L-Abu-CONH(CH₂)₃-morpholine
Description	A cell-permeable dipeptidyl a-ketoamide that acts as a potent, highly selective, reversible, active site inhibitor of calpain-1 (K_i = 140 nM) and calpain-2 (K_i = 41 nM). Weakly inhibits cathepsin B (K_i = 6.9 µM). Shown to inhibit calpain-m-mediated degradation of neurofilament protein (NFP) (IC₅₀ = 600 nM). Also shown to exhibit neuroprotective effects in the central nervous system following focal ischemia. Reported to protect against reovirus-induced myocarditis in mice.
Form	White to off-white solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	145731-49-3
Chemical formula	C₂₆H₄₀N₄O₆
Peptide Sequence	Z-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191. DeBiasi, R.L., et al. 2001. J. Virol. 75, 351. Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66. Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426. Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046. James, T., et al. 1998. J. Neurosci. Res. 51, 218. Li, Z., et al. 1996. J. Med. Chem. 39, 4089. Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428. Bartus, R.T., et al. 1995. Neurol. Res. 17, 249. Bartus, R.T., et al. 1994. Stroke 25, 2265.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors

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