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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

208733 Sigma-AldrichCalpain Inhibitor Set - Calbiochem

The Calpain Inhibitor Set controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Calpain Inhibitor Set - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

Primary Target: calpain 1, calpain 2

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概述

Replacement Information

价格及供货情况

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Description
Overview	Contains 5 mg of ALLN (Cat. No. 208719), 25 mg of Calpain Inhibitor III (Cat. No. 208722), 5 mg of Calpeptin (Cat. No. 03-34-0051), 1 mg of EST (Cat. No. 330005), and 5 mg of PD 150606 (Cat. No. 513022).
Catalogue Number	208733
Brand Family	Calbiochem®

References
References	Johnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011. Kampfl, A., et al. 1997. J. Neurotauma 14, 121. Sorimachi, H., et al., 1997. Biochem. J. 328, 721. Bartus, R.T., et al. 1995. Neurol. Res. 17, 249. Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412. Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628. Goll, D.E., et al. 1992. BioEssays 14, 549.

References

Johnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
Goll, D.E., et al. 1992. BioEssays 14, 549.

Product Information
Form	Solid
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	calpain 1, calpain 2
Primary Target K<sub>i</sub>	8 nM

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Multiple Toxicity Values, refer to MSDS
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
208733-1SETCN	04055977202755

Documentation

Calpain Inhibitor Set - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Calpain Inhibitor Set - Calbiochem 分析证书

标题	批号
208733	输入批号

参考

参考信息概述
Johnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011. Kampfl, A., et al. 1997. J. Neurotauma 14, 121. Sorimachi, H., et al., 1997. Biochem. J. 328, 721. Bartus, R.T., et al. 1995. Neurol. Res. 17, 249. Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412. Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628. Goll, D.E., et al. 1992. BioEssays 14, 549.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-May-2008 RFH
Description	Calpains are a family of calcium-dependent thiol-proteases that act on a wide variety of cytoskeletal, membrane-associated, and regulatory proteins. There are two major isoforms: calpain I (µ-form) and calpain II (m-form), which differ in their calcium requirement for activation Calpains are composed of heterodimers of 80 kDa and a 30 kDa subunits. The 80 kDa unit has the catalytic site and is unique to each isozyme, whereas the 30 kDa unit is the regulatory subunit and is common to both µ- and m-isozymes. More recently, attention has been focused on the pathological significance of calcium accumulation in the central nervous system following cerebral ischemia and traumatic brain injury. Over-activation of NMDA, kainate, and AMPA receptors in the brain leads to sustained influx of Ca²⁺ through the voltage-gated calcium channels. Overexpression of calpains has been positively linked to both acute and chronic neurodegenerative processes including ischemia, trauma, and Alzheimer's disease. In Alzheimer's disease the ratio of active (76 kDa) to inactive (80 kDa) µ-calpain is reported to be much higher Calpain-dependent proteolysis is usually the late-stage common pathway towards cell death induced by excitotoxic compounds, hence, a selective inhibition of calpains to limit neuronal damage appears to be a viable therapeutic measure.
Form	Solid
Intert gas (Yes/No)	Packaged under inert gas
Storage	Protect from moisture Protect from light -20°C
Do Not Freeze	Ok to freeze
Toxicity	Multiple Toxicity Values, refer to MSDS
References	Johnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011. Kampfl, A., et al. 1997. J. Neurotauma 14, 121. Sorimachi, H., et al., 1997. Biochem. J. 328, 721. Bartus, R.T., et al. 1995. Neurol. Res. 17, 249. Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412. Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628. Goll, D.E., et al. 1992. BioEssays 14, 549.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors

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