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239822 Sigma-AldrichCXCR4 Antagonist III - CAS 1357819-69-2 - Calbiochem

The CXCR4 Antagonist III controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N²-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N⁴-(piperidin-4-yl) quinazoline-2,4-diamine, 2HCl, Fusin Antagonist III

Primary Target: CXCR4

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1357819-69-2	C₃₀H₄₃N₇•2HCl

价格及供货情况

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Description
Overview	A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC₅₀ = 36.2 nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC₅₀ >10 µM). Shown to inhibit CXCL12-induced Ca²⁺-mobilization and cell migration in hCXCR4-HEK293 cells (IC₅₀ = 100.1 and 41 nM, respectively), and rapidly mobilize CXCR4⁺, CD34⁺ and CD133⁺ stem cells from bone marrow in C57BL/6 male mice (6 mg/kg, s.c).
Catalogue Number	239822
Brand Family	Calbiochem®
Synonyms	N²-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N⁴-(piperidin-4-yl) quinazoline-2,4-diamine, 2HCl, Fusin Antagonist III

References
References	Wu, C.H., et al. 2012. Chem. Med. Chem. 7, In press.

Product Information
CAS number	1357819-69-2
Form	White solid
Hill Formula	C₃₀H₄₃N₇•2HCl
Chemical formula	C₃₀H₄₃N₇•2HCl
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CXCR4
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
239822-10MGCN	04055977198966

Documentation

CXCR4 Antagonist III - CAS 1357819-69-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

CXCR4 Antagonist III - CAS 1357819-69-2 - Calbiochem 分析证书

标题	批号
239822	输入批号

参考

参考信息概述
Wu, C.H., et al. 2012. Chem. Med. Chem. 7, In press.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-August-2012 JSW
Synonyms	N²-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N⁴-(piperidin-4-yl) quinazoline-2,4-diamine, 2HCl, Fusin Antagonist III
Description	A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC₅₀ = 36.2 nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC₅₀ >10 µM). Shown to inhibit CXCL12-induced Ca²⁺-mobilization and cell migration in hCXCR4-HEK293 cells (IC₅₀ = 100.1 and 41 nM, respectively), and rapidly mobilize CXCR4⁺, CD34⁺ and CD133⁺ stem cells from bone marrow in C57BL/6 male mice (6 mg/kg, s.c).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1357819-69-2
Chemical formula	C₃₀H₄₃N₇•2HCl
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (25 mg/ml) or H₂O (25 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Wu, C.H., et al. 2012. Chem. Med. Chem. 7, In press.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > G-Protein and Related

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