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236005 Sigma-AldrichCOX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem

The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride

Primary Target: COX-1, COX-2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
130717-51-0	C₂₃H₂₅N₃O₃S • HCl

价格及供货情况

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Description
Overview	A cell-permeable trisubstituted thiazole compound that acts as a potent and selective inhibitor of COX-1 (IC₅₀ = 28 nM and 65 µM for human recombinant COX-1 and COX-2, respectively). Displays ~2,300 fold greater selectivity towards inhibition of COX-1 over COX-2. Reported to be orally active and display analgesic, anti-platelet and anti-inflammatory properties.
Catalogue Number	236005
Brand Family	Calbiochem®
Synonyms	FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride

References
References	Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782. Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49. Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189. Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.

Product Information
CAS number	130717-51-0
ATP Competitive	N
Form	Pale yellow solid
Hill Formula	C₂₃H₂₅N₃O₃S • HCl
Chemical formula	C₂₃H₂₅N₃O₃S • HCl
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	COX-1, COX-2
Primary Target IC<sub>50</sub>	28 nM and 65 µM for human recombinant COX-1 and COX-2
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
236005-5MGCN	04055977217100

Documentation

COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem 分析证书

标题	批号
236005	输入批号

参考

参考信息概述
Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782. Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49. Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189. Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-June-2008 RFH
Synonyms	FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride
Description	A potent, cell-permeable, and selective inhibitor of COX-1 (IC₅₀ = 28 nM; human recombinant COX-1). Does not significantly inhibit COX-2 (IC₅₀ = 65 µM, human recombinant COX-2). Reported to be orally active and displays analgesic properties in chemical nociceptive animal models. Also reported to exhibit anti-inflammatory effects and suppress prostaglandin E2 and thromboxane 2 levels in collagen-induced arthritis in rats. Shown to be 100 times more potent than aspirin in inhibiting arachidonic acid- and collagen-induced human and guinea pig platelet aggregation.
Form	Pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	130717-51-0
Chemical formula	C₂₃H₂₅N₃O₃S • HCl
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml), H₂O (4 mg/ml), or 1 N HCl (2 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782. Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49. Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189. Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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