219670 Sigma-AldrichCFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
CFTR Inhibitor-172, CAS 307510-92-5, is a cell-permeable, potent, reversible, rapid, and voltage-independent inhibitor of CFTR-mediated Cl- transport in human airway cells (Ki ~ 300 nM).
More>> CFTR Inhibitor-172, CAS 307510-92-5, is a cell-permeable, potent, reversible, rapid, and voltage-independent inhibitor of CFTR-mediated Cl- transport in human airway cells (Ki ~ 300 nM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 307510-92-5 | C₁₈H₁₀F₃NO₃S₂ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 219670-5MGCN |
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塑胶安瓿;塑胶针药瓶 | 5 mg |
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| Description | |
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| Overview | A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Also available as a 50 mM solution in DMSO (Cat. No. 219674). |
| Catalogue Number | 219670 |
| Brand Family | Calbiochem® |
| Synonyms | 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172 |
| References | |
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| References | Yang, H., et al. 2003. J. Biol. Chem. 278, 35079. Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599. Ma, T., et al. 2002. J. Clin. Invest. 110, 1651. |
| Product Information | |
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| CAS number | 307510-92-5 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₁₈H₁₀F₃NO₃S₂ |
| Chemical formula | C₁₈H₁₀F₃NO₃S₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 219670-5MGCN | 04055977201550 |
Documentation
CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem MSDS
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CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem 分析证书
| 标题 | 批号 |
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| 219670 |
参考
| 参考信息概述 |
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| Yang, H., et al. 2003. J. Biol. Chem. 278, 35079. Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599. Ma, T., et al. 2002. J. Clin. Invest. 110, 1651. |