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219673 Sigma-AldrichCFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem

A cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR δF508 mutant via direct interaction.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Cystic Fibrosis Transmembrane Conductor Regulator Mutant Corrector II, N-(2-(5-Chloro-2-methoxy-phenylamino)-4ʹ-methyl-[4,5ʹ]bithiazolyl-2ʹ-yl)-benzamide, Corr-4

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
421580-53-2	C₂₁H₁₇ClN₄O₂S₂

价格及供货情况

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Description
Overview	A cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR ΔF508 mutant via direct interaction and promote proper trafficking/glycosylation and surface expression in both transfected cells and primary airway epithelial cells from ΔF508-homozygous patients, while exhibiting little correcting effect toward N1303K-CFTR, P574H-CFTR, M345T-DRD4 (dopamine receptor 4), or G268V-ABCA1/CD243 /MDR1/ P-gp mutant. Reported to enhance the folding efficiency of both ΔF508 (by 3-fold at 10µM in FRT cells) and wild-type CFTR (by up to 70%), delay the ER-associated degradation of the core-glycosylated ΔF508 (by 30% at 10µM in FRT cells), and increase the stability of low-temperature resuced ΔF508 mutant on the plasma membrane (by 1.7-fold at 10µM in FRT cells). Corr-4a is shown to be more effective than VRT-325/CFcor-325 n restoring forskolin-stimulated CFTR activity in FRT and A549 ΔF508-CFTR transfectants. Unlike VRT-532 Corr-4a does not affect mutant CFTR channel gating activity.
Catalogue Number	219673
Brand Family	Calbiochem®
Synonyms	Cystic Fibrosis Transmembrane Conductor Regulator Mutant Corrector II, N-(2-(5-Chloro-2-methoxy-phenylamino)-4ʹ-methyl-[4,5ʹ]bithiazolyl-2ʹ-yl)-benzamide, Corr-4

References
References	Pedemonte, N., et al. 2010. Am. J. Physiol. Cell Physiol. 298, C866. Young, A., et al. 2009. Biochem. J. 421, 377. Wang, Y., et al. 2007. J. Biol. Chem. 282, 33247. Wang, Y., et al. 2007. Mol. Pharmacol. 71, 751. Wang, Y., et al. 2007. Biochem. J. 406, 257. Pedemonte, N., et al. 2005. J. Clin. Invest. 115, 2564.

Product Information
CAS number	421580-53-2
Form	Light beige solid
Hill Formula	C₂₁H₁₇ClN₄O₂S₂
Chemical formula	C₂₁H₁₇ClN₄O₂S₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219673-10MGCN	04055977200911

Documentation

CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

CFTR-F508del Corrector II, Corr-4a - CAS 421580-53-2 - Calbiochem 分析证书

标题	批号
219673	输入批号

参考

参考信息概述
Pedemonte, N., et al. 2010. Am. J. Physiol. Cell Physiol. 298, C866. Young, A., et al. 2009. Biochem. J. 421, 377. Wang, Y., et al. 2007. J. Biol. Chem. 282, 33247. Wang, Y., et al. 2007. Mol. Pharmacol. 71, 751. Wang, Y., et al. 2007. Biochem. J. 406, 257. Pedemonte, N., et al. 2005. J. Clin. Invest. 115, 2564.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-April-2011 RFH
Synonyms	Cystic Fibrosis Transmembrane Conductor Regulator Mutant Corrector II, N-(2-(5-Chloro-2-methoxy-phenylamino)-4ʹ-methyl-[4,5ʹ]bithiazolyl-2ʹ-yl)-benzamide, Corr-4
Description	A cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR ΔF508 mutant via direct interaction and promote proper trafficking/glycosylation and surface expression in both transfected cells and primary airway epithelial cells from ΔF508-homozygous patients, while exhibiting little correcting effect toward N1303K-CFTR, P574H-CFTR, M345T-DRD4 (dopamine receptor 4), or G268V-ABCA1/CD243 /MDR1/ P-gp mutant. Reported to enhance the folding efficiency of both ΔF508 (by 3-fold at 10µM in FRT cells) and wild-type CFTR (by up to 70%), delay the ER-associated degradation of the core-glycosylated ΔF508 (by 30% at 10µM in FRT cells), and increase the stability of low-temperature resuced ΔF508 mutant on the plasma membrane (by 1.7-fold at 10µM in FRT cells). Corr-4a is shown to be more effective than VRT-325/CFcor-325 n restoring forskolin-stimulated CFTR activity in FRT and A549 ΔF508-CFTR transfectants. Unlike VRT-532 Corr-4a does not affect mutant CFTR channel gating activity.
Form	Light beige solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	421580-53-2
Chemical formula	C₂₁H₁₇ClN₄O₂S₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Pedemonte, N., et al. 2010. Am. J. Physiol. Cell Physiol. 298, C866. Young, A., et al. 2009. Biochem. J. 421, 377. Wang, Y., et al. 2007. J. Biol. Chem. 282, 33247. Wang, Y., et al. 2007. Mol. Pharmacol. 71, 751. Wang, Y., et al. 2007. Biochem. J. 406, 257. Pedemonte, N., et al. 2005. J. Clin. Invest. 115, 2564.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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