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227016 Sigma-AldrichCCR2 Antagonist - CAS 445479-97-0 - Calbiochem

The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
445479-97-0	C₂₈H₃₄F₃N₅O₄S

价格及供货情况

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Description
Overview	A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC₅₀ = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca⁺² flux and chemotaxis (IC₅₀ = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
Catalogue Number	227016
Brand Family	Calbiochem®
Synonyms	2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist

References
References	Cherney, R.J., et al. 2008. J. Med. Chem. 51, 721.

Product Information
CAS number	445479-97-0
Form	White solid
Hill Formula	C₂₈H₃₄F₃N₅O₄S
Chemical formula	C₂₈H₃₄F₃N₅O₄S
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC (racemic mixture)

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
S Phrase	S: 22-24/25-36/37/39 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
227016-5MGCN	04055977200553

Documentation

CCR2 Antagonist - CAS 445479-97-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

CCR2 Antagonist - CAS 445479-97-0 - Calbiochem 分析证书

标题	批号
227016	输入批号

参考

参考信息概述
Cherney, R.J., et al. 2008. J. Med. Chem. 51, 721.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-August-2011 JSW
Synonyms	2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
Description	A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC₅₀ = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca⁺² flux and chemotaxis (IC₅₀ = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	445479-97-0
Chemical formula	C₂₈H₃₄F₃N₅O₄S
Structure formula
Purity	≥97% by HPLC (racemic mixture)
Solubility	DMSO (60 mg/ml) or Ethanol (6 mg/ml). Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Cherney, R.J., et al. 2008. J. Med. Chem. 51, 721.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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