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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

203811 Sigma-AldrichBryostatin 1 - CAS 83314-01-6 - Calbiochem

A macrocyclic lactone with antitumor properties.

Bryostatin 1 - CAS 83314-01-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Bryo 1, PKC Activator VII, PKC Activator VI

Primary Target: Protein kinase C

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
83314-01-6	C₄₇H₆₈O₁₇

价格及供货情况

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Description
Overview	A macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (K_i = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells.
Catalogue Number	203811
Brand Family	Calbiochem®
Synonyms	Bryo 1, PKC Activator VII, PKC Activator VI

References
References	Clamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673. Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137. Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233. Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624. Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245. Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840. Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.

References

Clamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673.
Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137.
Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233.
Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624.
Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245.
Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840.
Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.

Product Information
CAS number	83314-01-6
ATP Competitive	N
Form	White to colorless solid or film
Hill Formula	C₄₇H₆₈O₁₇
Chemical formula	C₄₇H₆₈O₁₇
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Protein kinase C
Primary Target K<sub>i</sub>	1.35 nM for protein kinase C
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	EH9455000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
203811-10UGCN	04055977204025

Documentation

Bryostatin 1 - CAS 83314-01-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Bryostatin 1 - CAS 83314-01-6 - Calbiochem 分析证书

标题	批号
203811	输入批号

参考

参考信息概述
Clamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673. Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137. Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233. Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624. Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245. Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840. Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-December-2018 JSW
Synonyms	Bryo 1, PKC Activator VII, PKC Activator VI
Description	A macrocyclic lactone that exhibits anti-tumor properties. Potently activates protein kinase C and exhibits high binding affinity (K_i = 1.35 nM). Effectively translocates protein kinase C (PKC) isozymes α, β, and ε and induces a biphasic, concentration-dependent, down-regulation of PKC δ. Reported to compete with phorbol esters in binding to PKC. Stimulates protein kinase D (PKD) activity in a biphasic, PKC-dependent manner in intact cells. Also activates Ras in Jurkat T cells and in rat2 cells.
Form	White to colorless solid or film
CAS number	83314-01-6
RTECS	EH9455000
Chemical formula	C₄₇H₆₈O₁₇
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (25 mg/ml) or Ethanol (25 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 1457
References	Clamp, A., and Jayson, G. 2002. Anticancer Drugs 13, 673. Lorenzo, P.S., et al. 1999. Cancer Res. 59, 6137. Wang, Q.J., et al. 1999. J. Biol. Chem. 274, 37233. Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624. Matthews, S.A., et al. 1997. J. Biol. Chem. 272, 20245. Szallasi, Z., et al. 1994. Mol. Pharmacol. 46, 840. Berkow, R.L., and Kratt, A.S. 1985. Biochem. Biophys. Res. Commun. 3, 1109.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Kinases Activators > Protein Kinase C Activators

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