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203734 Sigma-AldrichBrevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem

Brevetoxin PbTx-3, Ptychodiscus brevis, CAS 85079-48-7, is a lipid-soluble polyether marine toxin that acts as a voltage-dependent Na+ channel activator. Causes contractile paralysis in animal models.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Pumiliotoxin, Dihydrobrevetoxin B

Primary Target: Voltage-dependent Na+ channel activator

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
85079-48-7	C₅₀H₇₂O₁₄

价格及供货情况

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Description
Overview	Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
Catalogue Number	203734
Brand Family	Calbiochem®
Synonyms	Pumiliotoxin, Dihydrobrevetoxin B

References
References	Baden, D.G., et al. 1994. Nat. Toxins 2, 212. Rein, K., et al. 1994. J. Org. Chem. 59, 2107. Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64. Trainer, V.L. 1991. Mol. Pharmacol. 40, 988. Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126. Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166. Baden, D.G., et al. 1988. Toxicon 26, 97. Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129. Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514. Baden, D.G., et al. 1982. Toxicon 19, 455. Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

References

Baden, D.G., et al. 1994. Nat. Toxins 2, 212.
Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
Baden, D.G., et al. 1988. Toxicon 26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
Baden, D.G., et al. 1982. Toxicon 19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

Product Information
CAS number	85079-48-7
ATP Competitive	N
Form	Solid
Hill Formula	C₅₀H₇₂O₁₄
Chemical formula	C₅₀H₇₂O₁₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Brevetoxin PbTx-3, Ptychodiscus brevis, CAS 85079-48-7, is a lipid-soluble polyether marine toxin that acts as a voltage-dependent Na+ channel activator. Causes contractile paralysis in animal models.

Biological Information
Primary Target	Voltage-dependent Na+ channel activator
Purity	>95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	XW5885000

Safety Information
R Phrase	R: 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
S Phrase	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Highly Toxic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
End use certificate	Y

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
203734-100UGCN	04055977203868

Documentation

Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem 分析证书

标题	批号
203734	输入批号

参考

参考信息概述
Baden, D.G., et al. 1994. Nat. Toxins 2, 212. Rein, K., et al. 1994. J. Org. Chem. 59, 2107. Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64. Trainer, V.L. 1991. Mol. Pharmacol. 40, 988. Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126. Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166. Baden, D.G., et al. 1988. Toxicon 26, 97. Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129. Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514. Baden, D.G., et al. 1982. Toxicon 19, 455. Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	09-September-2010 JSW
Synonyms	Pumiliotoxin, Dihydrobrevetoxin B
Description	Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
Form	Solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	85079-48-7
RTECS	XW5885000
Chemical formula	C₅₀H₇₂O₁₄
Structure formula
Purity	>95% by HPLC
Solubility	DMSO (30 mg/ml), Methanol (30 mg/ml), Acetonitrile(30 mg/ml), Chloroform (30 mg/ml), Ethanol (10 mg/ml). Only sparingly soluble in H₂O
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
Toxicity	Highly Toxic
References	Baden, D.G., et al. 1994. Nat. Toxins 2, 212. Rein, K., et al. 1994. J. Org. Chem. 59, 2107. Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64. Trainer, V.L. 1991. Mol. Pharmacol. 40, 988. Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126. Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166. Baden, D.G., et al. 1988. Toxicon 26, 97. Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129. Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514. Baden, D.G., et al. 1982. Toxicon 19, 455. Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

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种类

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