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509890
Sigma-AldrichBenztropine - CAS 132-17-2 - Calbiochem
An antagonist of muscarinic M1 and M3 receptors that induces robust differentiation of oligodendrocytes precursor cell differentiation (EC₅₀ = 500 nM) and promotes myelination.
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Benztropine - CAS 132-17-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC50 = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).
Catalogue Number
509890
Brand Family
Calbiochem®
Synonyms
Benzatropine, Cogentin
References
References
Deshmukh, V.A, et al. 2013. Nature 502,327. Doshay, L.J., et al. 1956. J Am Med Assoc.162, 1031.
Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Deshmukh, V.A, et al. 2013. Nature 502,327. Doshay, L.J., et al. 1956. J Am Med Assoc.162, 1031.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
28-April-2014 JSW
Synonyms
Benzatropine, Cogentin
Description
A brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC50 = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
132-17-2
Chemical formula
C₂₁H₂NO·CH₃SO₃H
Purity
≥98% by HPLC
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Deshmukh, V.A, et al. 2013. Nature 502,327. Doshay, L.J., et al. 1956. J Am Med Assoc.162, 1031.
