506416 Sigma-AldrichBeclin-1 Activator II, retro-inverso TAT-Beclin-1 - Calbiochem
Beclin-1 Activator II, retro-inverso TAT-Beclin-1 is a cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 (Cat. No. 506048).
More>> Beclin-1 Activator II, retro-inverso TAT-Beclin-1 is a cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 (Cat. No. 506048). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II
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概述
重要规格表
| Empirical Formula |
|---|
| C₁₆₄H₂₅₁N₅₇O₄₅ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 5.06416.0001 |
|
玻璃瓶 | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 (Cat. No. 506048) that is expected to be more resistant to proteolytic degradation than Tat-Beclin1 and is shown to be more potent than Tat-Beclin1 in inducing autophagy in muscle, heart, and pancreas tissues in 6-wk-old GFP-LC3 transgenic mice (20 mg/kg i.p.) in vivo. Only the retro-inverso peptide, but not Tat-Beclin1, is effective in reducing autophagy substrate p62 level in the brain tissue of 5-d-old neontal GFP-LC3 mice (20 mg/kg i.p.). The retro-inverso peptide treatment is also reported to greatly reduce brain viral titre in neonatal mice subjected to West Nile Virus infection. |
| Catalogue Number | 506416 |
| Brand Family | Calbiochem® |
| Synonyms | (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II |
| References | |
|---|---|
| References | Shoji-Kawata, S., et al. 2013. Nature. 494, 201. |
| Product Information | |
|---|---|
| Declaration | Sold under license of US Patent 8,722,628. |
| Form | White powder |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₁₆₄H₂₅₁N₅₇O₄₅ |
| Chemical formula | C₁₆₄H₂₅₁N₅₇O₄₅ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | GAPR-1/GLIPR2 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Peptide Sequence | (D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| 产品目录编号 | GTIN |
| 5.06416.0001 | 04055977243321 |