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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

196000 Sigma-AldrichBafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 196000) on sigmaaldrich.com.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
88899-55-2	C₃₅H₅₈O₉

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
196000-10UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
196000-1SETCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	1 set	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
Overview	Note: 1 set = 3 x 10 µg
Catalogue Number	196000
Brand Family	Calbiochem®

References
References	Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049. Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255. Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379. Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577. Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575. Drose, S., et al. 1993. Biochemistry 32, 3902. Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

References

Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

Product Information
CAS number	88899-55-2
Form	White solid
Hill Formula	C₃₅H₅₈O₉
Chemical formula	C₃₅H₅₈O₉
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	vacuolar type H⁺ ATPase
Primary Target IC<sub>50</sub>	500 pM
Purity	≥90% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 22-26-36 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
196000-10UGCN	04055977206456
196000-1SETCN	04055977206449

Documentation

Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem 分析证书

标题	批号
196000	输入批号

参考

参考信息概述
Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049. Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255. Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379. Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577. Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575. Drose, S., et al. 1993. Biochemistry 32, 3902. Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	23-February-2010 JSW
Description	A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 0.5 nM) and is a valuable tool for distinguishing among different types of ATPases. Reported to selectivity inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). Blocks lysosomal cholesterol trafficking in macrophages. Known to interfere with pH regulation in brain cells. Inhibits bone resorption both in vivo and in vitro. Has been shown to exhibit cytotoxic effects on a number of cell lines in a cell viability assay.
Form	White solid
CAS number	88899-55-2
Chemical formula	C₃₅H₅₈O₉
Structure formula
Purity	≥90% by HPLC
Solubility	DMSO (100 µM) or Ethanol
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049. Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255. Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379. Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577. Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575. Drose, S., et al. 1993. Biochemistry 32, 3902. Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > ATPase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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