506384 Sigma-AldrichBLM Helicase Inhibitor, ML216 - CAS 1430213-30-1 - Calbiochem
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 1430213-30-1 | C₁₅H₉F₄N₅OS |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
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| 5.06384.0001 |
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玻璃瓶 | 10 mg |
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| Description | |
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| Overview | A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom′s syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50 = 2.98 and 0.97 µM, respectively). Competes with and reversibly blocks DNA binding to BLM. However, the inhibition appears to be non-competitive with respect to ATP. Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin (Cat. No. 178273) without affecting PSNG13 cells that are devoid of BLM. Displays favorable microsomal (T1/2 > 1.2 h) and plasma stability (~100% at 5 h). |
| Catalogue Number | 506384 |
| Brand Family | Calbiochem® |
| Synonyms | 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea, ML-216 |
| References | |
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| References | Rosenthal, A.S., et al. 2013. Bioorg. Med. Chem. Lett. 23, 5660. Nguyen, G.H., et al. 2013. Chem. Biol. 20, 55. |
| Product Information | |
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| CAS number | 1430213-30-1 |
| Form | Orange solid |
| Hill Formula | C₁₅H₉F₄N₅OS |
| Chemical formula | C₁₅H₉F₄N₅OS |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | BLM |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 5.06384.0001 | 04055977243284 |
Documentation
BLM Helicase Inhibitor, ML216 - CAS 1430213-30-1 - Calbiochem MSDS
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参考
| 参考信息概述 |
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| Rosenthal, A.S., et al. 2013. Bioorg. Med. Chem. Lett. 23, 5660. Nguyen, G.H., et al. 2013. Chem. Biol. 20, 55. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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