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196870 Sigma-AldrichBAY 11-7082 - CAS 19542-67-7 - Calbiochem

BAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.

BAY 11-7082 - CAS 19542-67-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

Primary Target: TNF-α-inducible phosphorylation of IκBα

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
19542-67-7	C₁₀H₉NO₂S

价格及供货情况

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Description
Overview	Potential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC₅₀ = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available.
Catalogue Number	196870
Brand Family	Calbiochem®
Synonyms	(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

References
References	Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356. Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482. Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

Product Information
CAS number	19542-67-7
Form	Off-white solid
Hill Formula	C₁₀H₉NO₂S
Chemical formula	C₁₀H₉NO₂S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	BAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.

Biological Information
Primary Target	TNF-α-inducible phosphorylation of IκBα
Primary Target IC<sub>50</sub>	10 µM inhibiting TNF-α-inducible phosphorylation of IκBα
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
196870-10MGCN	04055977206562

Documentation

BAY 11-7082 - CAS 19542-67-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

BAY 11-7082 - CAS 19542-67-7 - Calbiochem 分析证书

标题	批号
196870	输入批号

参考

参考信息概述
Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356. Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482. Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

小册子

标题
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

引用

标题

Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.

Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.

Meng-Hsing Wu, et al. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. 90, 286-295.

Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-September-2010 RFH
Synonyms	(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Description	Potential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC₅₀ = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC₅₀ ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	19542-67-7
Chemical formula	C₁₀H₉NO₂S
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (200 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356. Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482. Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
Citation	Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,. Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456. Meng-Hsing Wu, et al. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. 90, 286-295. Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cell Adhesion Inhibitors

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