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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

189490 Sigma-AldrichAutophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem

Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
技术信息
Data Sheet

同义词: 3-Methyladenine

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
5142-23-4	C₆H₇N₅

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
189490-100MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	100 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC₅₀ = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
Catalogue Number	189490
Brand Family	Calbiochem®
Synonyms	3-Methyladenine

References
References	Canu, N., et al. 2005. J. Neurochem. 92, 1228. Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845. Beugnet, A., et al. 2003. Biochem. J. 372, 555. Eskelinen, E.L., et al. 2002. Traffic 3, 878. Petiot, A., et al. 2000. J. Biol. Chem. 275, 992. Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.

Product Information
CAS number	5142-23-4
Form	White to faint yellow powder
Hill Formula	C₆H₇N₅
Chemical formula	C₆H₇N₅
Structure formula Image
Quality Level	MQ100

Applications
Application	Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
189490-100MGCN	04055977221831
189490-50MGCN	07790788048235

Documentation

Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem 分析证书

标题	批号
189490	输入批号

参考

参考信息概述
Canu, N., et al. 2005. J. Neurochem. 92, 1228. Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845. Beugnet, A., et al. 2003. Biochem. J. 372, 555. Eskelinen, E.L., et al. 2002. Traffic 3, 878. Petiot, A., et al. 2000. J. Biol. Chem. 275, 992. Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.

技术信息

标题
LentiBrite™ Lentiviral Biosensors for Fluorescent Cellular Imaging: Analysis of Autophagosome Formation

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-May-2012 JSW
Synonyms	3-Methyladenine
Description	A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC₅₀ = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
Form	White to faint yellow powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	5142-23-4
Chemical formula	C₆H₇N₅
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml) or H₂O (5 mg/ml). In applications where high working concentrations are necessary (e.g. 10 mM), the use of a pre-made stock solution may result in the introduction of higher than desired solvent (e.g., DMSO) into the experimental systems. In such cases, it is recommended that the solid compound be weighed out at the time of use and reconstituted directly into the solutions used in the experimental system (buffers, media, etc.). Vortexing may be required for complete solubilization in water.
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Canu, N., et al. 2005. J. Neurochem. 92, 1228. Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845. Beugnet, A., et al. 2003. Biochem. J. 372, 555. Eskelinen, E.L., et al. 2002. Traffic 3, 878. Petiot, A., et al. 2000. J. Biol. Chem. 275, 992. Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Autophagy Inhibitors

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