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189485 Sigma-AldrichAutocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable, is a specific, potent inhibitor of CaMKII. Contains the Antennapedia transport peptide fused to the amino terminus of AIP-II.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH, Ant-A3K/V10F-AIP, Ant-AIP-II

Primary Target: cam Kinase-2

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概述

Replacement Information

重要规格表

Empirical Formula
C₁₇₇H₂₉₁N₅₇O₃₉S

价格及供货情况

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Description
Overview	A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitor that contains the Antennapedia transport peptide sequence fused to the amino terminus of AIP-II (Cat. No. 189484).
Catalogue Number	189485
Brand Family	Calbiochem®
Synonyms	Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH, Ant-A3K/V10F-AIP, Ant-AIP-II

References
References	Watterson, D.M., et al. 2001. Neurochem. Int. 39, 459. Ishida, A., et al. 1998. FEBS Lett. 427, 115.

Product Information
ATP Competitive	N
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₁₇₇H₂₉₁N₅₇O₃₉S
Chemical formula	C₁₇₇H₂₉₁N₅₇O₃₉S
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ200

Applications
Application	Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable, is a specific, potent inhibitor of CaMKII. Contains the Antennapedia transport peptide fused to the amino terminus of AIP-II.

Biological Information
Primary Target	cam Kinase-2
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
189485-1MGCN	04055977221800

Documentation

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem 分析证书

标题	批号
189485	输入批号

参考

参考信息概述
Watterson, D.M., et al. 2001. Neurochem. Int. 39, 459. Ishida, A., et al. 1998. FEBS Lett. 427, 115.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-April-2008 RFH
Synonyms	Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH, Ant-A3K/V10F-AIP, Ant-AIP-II
Description	A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II) (Cat. No. 189484). AIP-II is an AIP analog where Ala³ and Val¹⁰ are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala²⁸⁶) and KN-93 (Cat. No. 422708). Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₇₇H₂₉₁N₅₇O₃₉S
Peptide Sequence	Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
Purity	≥97% by HPLC
Solubility	DMSO (5 mg/ml), H₂O (1 mg/ml), or 5% Acetic Acid (1 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity	Standard Handling
References	Watterson, D.M., et al. 2001. Neurochem. Int. 39, 459. Ishida, A., et al. 1998. FEBS Lett. 427, 115.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors

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