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189410 Sigma-AldrichAurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
331771-20-1	C₂₉H₃₁N₅O₄

价格及供货情况

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Description
Overview	A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC₅₀ = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC₅₀ = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC₅₀ > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser¹⁰ in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
Catalogue Number	189410
Brand Family	Calbiochem®
Synonyms	4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline

References
References	Gadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305. Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.

Product Information
CAS number	331771-20-1
Form	White solid
Hill Formula	C₂₉H₃₁N₅O₄
Chemical formula	C₂₉H₃₁N₅O₄
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Regulatory Review
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
189410-5MGCN	04055977221763

Documentation

Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem 分析证书

标题	批号
189410	输入批号

参考

参考信息概述
Gadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305. Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.

小册子

标题
New Products: Volume 3, 2012

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-September-2018 JSW
Synonyms	4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline
Description	A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC₅₀ = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC₅₀ = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC₅₀ > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser¹⁰ in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	331771-20-1
Chemical formula	C₂₉H₃₁N₅O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Regulatory Review
References	Gadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305. Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Aurora Kinase Inhibitors

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