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189410 Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

概述

重要规格表

CAS #Empirical Formula
331771-20-1C₂₉H₃₁N₅O₄

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
189410-5MGCN
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      Description
      OverviewA cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC50 > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
      Catalogue Number189410
      Brand Family Calbiochem®
      Synonyms4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline
      References
      ReferencesGadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
      Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.
      Product Information
      CAS number331771-20-1
      FormWhite solid
      Hill FormulaC₂₉H₃₁N₅O₄
      Chemical formulaC₂₉H₃₁N₅O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      产品目录编号 GTIN
      189410-5MGCN 04055977221763