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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

189400 Sigma-AldrichAurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem

A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: ATA

Primary Target: DNA topoisomerase 2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
4431-00-9	C₂₂H₁₄O₉

价格及供货情况

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Description
Overview	A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC₅₀= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC₅₀ = 22 µM and IC₅₀ = 10 µM for µ-calpain and m-calpain, respectively).
Overview	Dye content: ~85%.
Catalogue Number	189400
Brand Family	Calbiochem®
Synonyms	ATA

References
References	Lozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30. Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305. Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464. Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291. Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853. Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101. Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475. Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.

References

Lozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.

Product Information
CAS number	4431-00-9
ATP Competitive	N
Form	Red solid
Hill Formula	C₂₂H₁₄O₉
Chemical formula	C₂₂H₁₄O₉
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	DNA topoisomerase 2
Primary Target IC<sub>50</sub>	75 nM against DNA topoisomerase II
Purity	≥85% by Titration

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	GU4790000

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
189400-100MGCN	04055977221725

Documentation

Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem 分析证书

标题	批号
189400	输入批号

参考

参考信息概述
Lozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30. Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305. Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464. Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291. Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853. Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101. Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475. Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-April-2019 JSW
Synonyms	ATA
Description	A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is also a potent inhibitor of DNA topoisomerase II. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA has been reported to stimulate the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase C-γ. Dye content: ~85%.
Form	Red solid
CAS number	4431-00-9
RTECS	GU4790000
Chemical formula	C₂₂H₁₄O₉
Structure formula
Purity	≥85% by Titration
Solubility	0.1 M NaOH (35 mg/ml)
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Irritant
References	Lozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30. Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305. Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464. Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291. Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853. Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101. Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475. Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Topoisomerase Related Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Nuclease Inhibitors

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